Results 221 to 230 of about 48,461 (279)

Photoswitchable Peptides as Molecular Tools to Encode Structural Order and Disorder in Intracellular Assemblies. [PDF]

Angew Chem Int Ed Engl
Link J, Burg L, Chagri S, Nguyen HC, Ng DYW, Ravoo BJ, Weil T.   +6 more
europepmc   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Structural and Catalytic Roles of the Disulfide Bonds Cys19-Cys154 and Cys134-Cys199 in Trypsin-like Proteases: Evolutionary Insights for Disulfide Bond Acquisition. [PDF]

Molecules
Minakata M, Murakami Y, Ashida O, Matsuzaki M, Ogawa K, Saeki N, Shimamoto S, Miyazawa M, Hidaka Y, Sakata N.   +9 more
europepmc   +1 more source

Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application

MedComm, Volume 7, Issue 2, February 2026.
Hydrogels offer an innovative platform for cancer immunotherapy. Through tailorable crosslinking strategies, they form customizable drug delivery platforms that address diverse therapeutic requirements by loading specific immunotherapeutic agents. These systems demonstrate significant clinical potential for precise tumor immunotherapy.
Xiaohua Chen, Shan Wu, Yueyang Zhang, Lilu Feng, Yang Chen, Xuzhao Yang, Ke Men, Jiuqun Zhu, Ming Li   +8 more
wiley   +1 more source

Metabolic cell deaths in head and neck cancer: mechanisms, therapeutic potential, and challenges. [PDF]

Ann Med
Wang T, Li X, Huang X, Wang Z, Zhang Y, Lei J, Qian X, Lu C, Liu Z.   +8 more
europepmc   +1 more source

Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state

Acta Crystallographica Section D, Volume 82, Issue 2, Page 140-150, February 2026.
Structural characterization of S. mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state and identifies a schistosome‐specific epitope.Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino‐acid ...
Kelly L. Parker, John D. Clarke, Xiaojiao Liu, Barbara F. Gomes, Lauren E.-A. Eyssen, Nicholas Furnham, Floriano Paes Silva-Jr, Raymond J. Owens   +7 more
wiley   +1 more source

Thiol Isomerases: Enzymatic Mechanisms, Models of Oxidation, and Antagonism by Galloylated Polyphenols. [PDF]

Antioxidants (Basel)
Owegie OC, Kennedy QP, Davizon-Castillo P, Yang M.   +3 more
europepmc   +1 more source

Thymoquinone Protects Against Cardiac Hypertrophy via PPAR‐γ/PI3K/Akt Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Thymoquinone (TQ), the principal active constituent of Nigella stativa, has demonstrated numerous biological properties and therapeutic effects on various diseases. However, its therapeutic potential against cardiac hypertrophy remains uncertain.
Rong‐bin Qiu, Zi‐ming Wu, Zhi‐qiang Xu, Li‐juan Hu, Shi‐tao Zhao, Rui‐yuan Zeng, Zhi‐cong Qiu, Lian‐fen Zhou, Song‐qing Lai, Wen‐jun Wang, Li Wan   +10 more
wiley   +1 more source