Results 311 to 320 of about 77,313 (353)

Glutamine metabolism is systemically different between primary and induced pluripotent stem cell-derived brain microvascular endothelial cells. [PDF]

open access: yesJ Cereb Blood Flow Metab
Weber CM   +7 more
europepmc   +1 more source

Inhibition of glutathione disulfide reductase by glutathione

Archives of Biochemistry and Biophysics, 1991
Rat-liver glutathione disulfide reductase is significantly inhibited by physiological concentrations of the product, glutathione. GSH is a noncompetitive inhibitor against GSSG and an uncompetitive inhibitor against NADPH at saturating concentrations of the fixed substrate.
Hiram F. Gilbert   +2 more
openaire   +3 more sources

Functions of glutathione and glutathione disulfide in immunology and immunopathology

The FASEB Journal, 1994
Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione (GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of lymphocytes in vitro. At low GSSG levels, T cells cannot optimally activate the immunologically important transcription factor NF kappa B, whereas high GSSG levels ...
Hans-Peter Eck   +7 more
openaire   +2 more sources

Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide

Biochemical Pharmacology, 1983
The amount of glutathione present in hepatic protein mixed disulfides was determined to be 20-30 nmole/g liver. This was established using two specific enzymatic methods: (a) the coupled assay with DTNB and glutathione (GSSG) reductase and (b) a newly developed test using GSH transferase and 1-chloro-2,4-dinitrobenzene for the estimation of GSH ...
Christian Muckel   +3 more
openaire   +3 more sources

Inhibition of protein synthesis by glutathione disulfide in the presence of glutathione

Biochemical and Biophysical Research Communications, 1971
Abstract As little as 5 × 10−5 M glutathione disulfide (GSSG) in the presence of 80 × 10−5 M glutathione (GSH) in a rabbit reticulocyte lysate caused a profound inhibition of initiation of protein synthesis. A potential physiological regulatory role for GSSG in protein synthesis is thus revealed.
Edward M. Kosower   +4 more
openaire   +3 more sources

[48] Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples

1981
Publisher Summary This chapter presents the assay of glutathione (GSH), glutathione disulfide (GSSG), and glutathione mixed disulfides (GSSR). The sum of the reduced and oxidized forms of glutathione can be determined by using a kinetic assay in which catalytic amounts of GSH or GSSG and glutathione reductase bring about the continuous reduction of 5,
Helmut Sies, Theodorus P.M. Akerboom
openaire   +3 more sources

Measurement of glutathione-protein mixed disulfides

International Journal of Radiation Oncology*Biology*Physics, 1984
We have undertaken the development of a sensitive and highly specific assay for the presence of mixed disulfides between protein thiol groups and endogenous thiols. Previous investigations on the concentrations of glutathione (GSH), glutathione disulfide (GSSG) and protein glutathione mixed disulfides (ProSSG) have been of limited usefulness because of
John C. Livesey, Donald J. Reed
openaire   +3 more sources

New Photoactivatable Analogues of Glutathione Disulfide [PDF]

open access: possibleSynthesis, 2006
New photoactivatable analogues of glutathione disulfide (GSSG) bearing new benzophenone-like photophores were synthesized by using an improved coupling reaction.
Gilbert Kirsch   +2 more
openaire   +1 more source

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