Results 121 to 130 of about 21,521,606 (315)

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Self‐Assembled Pt(II) Complexes Boost Up Stem Cell Proliferation and Accelerate Metamorphosis in Living Organisms

Angewandte Chemie, EarlyView.
Pt1, an organometallic platinum‐based complex, act as a modulator of redox homeostasis in cnidarians, regulating cellular functions and life‐cycle dynamics. In Nematostella vectensis, it mitigates oxidative stress, strengthens detox systems and accelerates development.
Giuseppina Tommasini, Tania Pecoraro, Anna Lewinska, Maciej Wnuk, Olga Kolodziej, Daniela Intartaglia, Simona Morgera, Alessandro Aliprandi, Giulia Veronesi, Giorgio Facchetti, Isabella Rimoldi, Angela Tino, Claudia Tortiglione, Luisa De Cola   +13 more
wiley   +2 more sources

Diversidad e implicaciones de los polimorfismos de las enzimas glutatión S transferasas en la patogénesis del asma:-- Diversity and implications of glutathione S-transferase enzymes polymorphisms in the pathogenesis of asthma

MedUNAB, 2011
Las glutatión S-transferasas (GST) representan una superfamilia de enzimas presentes en todos los organismos aerobios. Existen tres familias principales que se encuentran ampliamente distribuidas en la naturaleza y se clasifican en citosólicas ...
Yosed Anaya Chávez, Biol, Beatriz Martínez, MSc   +1 more
doaj  

Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population

Genetics and Molecular Biology
Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of ...
Ivana Grubisa, Petar Otasevic, Nada Vucinic, Biljana Milicic, Tanja Jozic, Slobodan Krstic, Jelena Milasin   +6 more
doaj   +1 more source

Polymorphisms of Cytochromes P450 and Glutathione S-Transferases Synergistically Modulate Risk for Parkinson's Disease. [PDF]

Front Aging Neurosci, 2022
Fan HH, Li BQ, Wu KY, Yan HD, Gu MJ, Yao XH, Dong HJ, Zhang X, Zhu JH.   +8 more
europepmc   +1 more source

The phylogenetic analysis of glutathione-S-transferases.

, 2015
Unrooted distance neighbor-joining tree showing the phylogeny of glutathione-S-transferases from the genomes of Anopheles sinensis (red circle) and Anopheles gambiae (blue triangle).
Bo Shen (419737), Yan Sun (22436), Dan Zhou (29408), Lei Ma (221178), Changliang Zhu (278380), Xianmiao Liu (829072)   +5 more
core   +1 more source

Platycodon grandiflorus–Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

Advanced Science, EarlyView.
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun   +9 more
wiley   +1 more source

Genome-wide identification and characterization of Glutathione S-Transferases (GSTs) and their expression profile under abiotic stresses in tobacco (Nicotiana tabacum L.). [PDF]

BMC Genomics, 2023
Mo Z, Huang Y, Pu T, Duan L, Pi K, Luo J, Long B, Lu A, Liu R.   +8 more
europepmc   +1 more source

Purificação e caracterização da glutationa S-transferase (E.C.2.5.1.18) de brânquias de ostras Crassostrea rhizoporae (Guilding, 1828) [PDF]

, 2006
Dissertação (mestrado) - Univesidade Federal de Santa Catarina. Programa de Pós-Graduação em Biotecnologia.A ostra Crassostrea rhizophorae vem sendo amplamente utilizada como um organismo sentinela em programas de biomonitoramento marinho.
Trivella, Daniela Barretto Barbosa
core