Results 151 to 160 of about 61,356 (195)

The glutathione peroxidase activity of glutathione S-transferases

Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
Glutatione transferases (RX:glutathione R-transferases, EC 2.5.1.18) B and AA were purified from rat liver to investigate the mechanism for their apparent GSH peroxidase activity (GSSG formation). Both transferases catalyze an overall reaction in which loss of cumene hydroperoxide is accompanied by a stoichiometric increase in GSSG.
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Identity of microsomal glutathione-S-transferases

Molecular and Cellular Biochemistry, 1982
Mouse liver microsomes were prepared by repeated washing, homogenization, and centrifugation until almost no more soluble enzymes were found in the supernatant of the last centrifugation. About 0.09% of the total glutathione S-transferase activity and comparable amount of soluble enzymes were detected in microsomes solubilized with Emulgen 913.
C Y, Lee, J D, McKinney
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Glutathione S-transferases in esophageal cancer

Carcinogenesis, 1993
Glutathione content and glutathione S-transferase enzyme activity as well as isoenzyme composition were studied in normal gastric cardia, normal squamous esophageal epithelium and corresponding malignant tumor of 10 patients with esophageal cancer. Mean values of glutathione (38 +/- 6 versus 36 +/- 12 nmol/mg protein) and glutathione S-transferase ...
W H, Peters, T, Wobbes, H M, Roelofs, J B, Jansen   +3 more
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Glutathione S-Transferases

1977
Any symposium which deals with the metabolic formation and inactivation of reactive metabolites must necessarily consider the prominent role played by glutathione (GSH) and the glutathione transferases since this simple tripeptide (Fig. 1) and the enzymes which employ GSH as a cosubstrate represent a very important factor in the protection of cellular ...
Donald M. Jerina, John R. Bend
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Glutathione-S-transferase family of enzymes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
The loci encoding the glutathione-S-transferase (GST) enzymes comprise a large supergene family located on at least seven chromosomes. The function of the GST enzymes has traditionally been considered to be the detoxication of electrophiles by glutathione conjugation. A wide variety of endogenous (e.g.
R C, Strange, M A, Spiteri, S, Ramachandran, A A, Fryer   +3 more
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Trialkyl phosphorothioates and glutathione S-transferases

Chemico-Biological Interactions, 1985
Using a rat liver cytosol source of enzyme trialkyl phosphorothioates have been shown to be substrates of glutathione S-transferases. Using OSS-trimethyl phosphorodithioate (OSS-Me(O] and OOS-trimethyl phosphorothioate (OOS-Me(O] the methyl transferred to the sulphydryl of glutathione is that attached to phosphorus via an oxygen atom.
W N, Aldridge, H, Grasdalen, K, Aarstad, B W, Street, T, Norkov   +4 more
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Low glutathione S -transferase dogs

Archives of Toxicology, 2004
Liver and kidney glutathione S-transferase (GST) activities to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activities) were measured in 280 dogs from five different breeders, and significant individual differences in this activity were observed in both organs. Interestingly, 34 out of the 280 dogs (i.e. 12.1%) were those in which liver GST-
Toshiyuki, Watanabe, Tomomi, Sugiura, Sunao, Manabe, Wataru, Takasaki, Yoshihiko, Ohashi   +4 more
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Human genes for glutathione S-transferases

Human Genetics, 1984
The tissue distribution of different glutathione S-transferases (GST) is analysed by electrophoresis. The existence of GST"e" (erythrocyte), GST3, GST1, and GST2 is confirmed. GST"e" the fastest and most thermolabile of different GST analysed is observed only in erythrocyte cells.
V, Laisney, , Nguyen Van Cong, M S, Gross, J, Frezal   +3 more
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Molecular Phylogeny of Glutathione-S-Transferases

DNA and Cell Biology, 1997
The glutathione-S-transferase (GST) protein superfamily is currently composed of nearly 100 sequences. This study documents a greater phylogenetic diversity of GSTs than previously realized. Parsimony and distance phylogenetic methods of GST amino acid sequences yielded virtually the same results. There appear to be at least 25 groups (families) of GST-
M J, Snyder, D R, Maddison
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Glutathione S-transferase in human bile

Clinica Chimica Acta, 1989
Glutathione S-transferase (GST) isoenzymes have been measured by specific radioimmunoassay in human bile samples. GST Mu was found in 50% of samples while GST Pi, GST B1 and GST B2 were present in all samples; GST Pi constituted the major isoenzyme identified.
Howie, A F, Hayes, P C, Bouchier, I A, Hayes, J D, Beckett, G J   +4 more
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