Results 101 to 110 of about 315,758 (337)

Senescence‐Inducing Therapy Sequential NIR‐II Mild Photothermal/Senolytic Therapy of Triple Negative Breast Cancer

Advanced Science, EarlyView.
Targeting triple‐negative breast cancer remains challenging due to limited therapies and drug resistance. A sequential theranostic strategy combining palbociclib‐induced senescence (enhancing heat sensitivity via HSP70 downregulation) with an NIR‐II nanoplatform (IQ NPs) for mild photothermal therapy (PTT) and quercetin‐mediated senolysis is developed.
Liya Yu, Yehui Kang, Mengdie Yu, Yuejia Ding, Yang Chen, Qingyuan Wu, Yu Cai, Huiyu Liu, Zhenye Lv   +8 more
wiley   +1 more source

Early Glycemic Control in Critically Ill Emergency Department Patients: Pilot Trial

Western Journal of Emergency Medicine, 2010
Objective: Glycemic control in the critically ill intensive care unit (ICU) patient has been shown to improve morbidity and mortality. We sought to investigate the effect of early glycemic control in critically ill emergency department (ED) patients in a
Cohen, Jason, Goedecke, Eric, Cyrkler, Jennifer E, Mangolds, Virginia B, Bateman, Jane, Przyklenk, Karin   +5 more
doaj  

Improving the clinical value and utility of CGM systems: issues and recommendations : a joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group [PDF]

, 2017
The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionise the use of intensive insulin therapy in diabetes; however, progress towards that vision has been gradual.
Bergenstal, Richard M., Fleming, G. Alexander, Heinemann, Lutz, Holl, Reinhard W., Peters, Anne L., Petrie, John R.   +5 more
core   +2 more sources

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Effects of celery (Apium graveolens) on blood pressure, glycemic and lipid profile in adults: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Nutrition
BackgroundCelery is commonly used as a diet intervention for hypertension, hyperglycemia, and hyperlipidemia. However, its precise therapeutic efficacy remains uncertain.ObjectiveThis study aims to comprehensively evaluate the efficacy of celery ...
Dangzhen Liu, Haiyan Zhao, Hong Xu, Jingqing Hu, Jingqing Hu, Jingqing Hu, Jingqing Hu   +6 more
doaj   +1 more source

Glycemic index, glycemic load and childhood obesity: A systematic review

Advanced Biomedical Research, 2014
Background: Several evidences have been reported so far in terms of the relationship between obesity and glycemic index and glycemic load in children. However, the number of review studies that have dealt with recent findings is quite low. The purpose of
Mohammad Hossein Rouhani, Roya Kelishadi, Mahin Hashemipour, Ahmad Esmaillzadeh, Leila Azadbakht   +4 more
doaj   +1 more source

Rational Design of Advanced Functional Catalysts for Photo‐Reforming Glucose into Bio‐Derived Fuels and Chemicals

Advanced Science, EarlyView.
This review systematically summarizes the fundamental mechanisms of photocatalytic glucose conversion, catalyst design strategies, key reaction pathways, structure‐activity relationships, influence of reaction parameter adjustments, and current challenges in the field.
Qiong Yan, Yuyue Zhou, Yan Zhang, Dalin Sun, Xu Wu, Song Yang, Chunbao Xu, Heng Zhang   +7 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Predictable Modulation of a Spontaneous Post‐translational Modification in Living Cells

Angewandte Chemie, EarlyView.
A new tool is reported for studying methylglyoxal (MGO)‐derived protein glycation by incorporating single amino acid mutations that predictably modulate glycation levels. Mass spectrometry of intact proteins and proteolytic digests reveal Tyr (or Glu) substitutions result in an increase (or decrease) in site‐specific glycation, enabling precise control
Meghan S. Martin, Nomindari Bayaraa, Brittany T. Fox, Yu‐Shan Lin, Rebecca A. Scheck   +4 more
wiley   +2 more sources

Predictors of Post Prandial Glucose Level in Diabetic Elderly [PDF]

, 2019
Post prandial glucose (PPG) level describes the speed of glucose absorption after 2 hours of macronutrient consumption. By knowing this, we could get the big picture of insulin regulation function and macronutrient metabolism in our body. In elderly, age-
Manungkalit, M. (Maria), Sari, N. P. (Ni)   +1 more
core