Results 301 to 310 of about 307,887 (342)

Differential effects of bariatric surgery on circulating GDF15 and FGF21 levels: Implications for glycemic status and weight loss outcomes

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Our research shows different post‐surgical patters in GDF15 and FGF21 concentrations following Roux‐en‐Y gastric bypass. GDF15 levels increase significantly in patients with obesity and normoglycemia and in those with obesity and impaired glucose tolerance or type 2 diabetes, while FGF21 concentrations significantly decrease in patients with obesity ...
Laura Salmón‐Gómez   +12 more
wiley   +1 more source

Enhanced mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) from young children with overweight/obesity and insulin resistance

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
We investigated measures of mitochondrial function in certain types of blood cells and metabolism in 65 children, 5–10 years old. Compared to children of normal weight (n = 20), children with overweight/obesity (n = 28) and especially those with insulin resistance (n = 17), differed in how their cells produced energy.
Eugenia Carvalho   +5 more
wiley   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano   +3 more
wiley   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

open access: yesThe FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

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