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Glycemic Variability

Diabetes Care, 2008
Diabetes is characterized by glycemic disorders that include both sustained chronic hyperglycemia and acute glucose fluctuations. There is now cogent evidence for the deleterious effects of sustained chronic hyperglycemia that results in excessive protein glycation and generation of oxidative stress. The role of glucose variability from peaks to nadirs
Louis Monnier, Claude Colette
openaire   +1 more source

Subcutaneous insulin: pharmacokinetic variability and glycemic variability

Diabetes & Metabolism, 2005
The therapeutic goal in insulin-treated diabetic patients is to maintain on the long-term a tight glucose control (HbA1, < 6.5-7% or less) through an insulin regimen which "mimic" the physiological insulin profile: a basal insulin secretion to maintain glucose homeostasis and an acute post-prandial secretion in response to meal intake.
B, Guerci, J P, Sauvanet
openaire   +2 more sources

Current concepts and clinical importance of glycemic variability

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2021
Evolving evidence indicate that variations in blood glucose levels are likely to be an important factor in developing diabetic complications. Monitoring glucose fluctuations in patients remains as a therapeutic challenge and more evidence needs to be created in order to bring GV into limelight.
Ramya Ravi   +3 more
openaire   +2 more sources

Glycemic risk factors of diabetic vascular complications: the role of glycemic variability

Diabetes/Metabolism Research and Reviews, 2009
AbstractAchieving adequate targets relatively to all risk factors is considered a standard of care for patients with diabetes mellitus. To date, current guidelines underline the importance of the ‘glucose triad’ (post‐prandial glucose, fasting plasma glucose and glycated haemoglobin) as the three glycemic factors that should be controlled in diabetes ...
Francesco, Zaccardi   +2 more
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Glycemic Variability: Looking Beyond the A1C

Diabetes Spectrum, 2012
In Brief Hyperglycemia in diabetes is known to be associated with both micro- and macrovascular complications. However, multiple studies have raised the question of whether variation in glucose levels, in addition to average glucose, might be a risk factor for these complications.
Tracy S. Tylee, Dace L. Trence
openaire   +1 more source

Prognostic significance of glycemic variability after cardiac surgery

Journal of Diabetes and its Complications, 2016
The prognostic significance of acute glycemic variability (GV) after cardiac surgery is not known. This study was therefore planned to analyze the independent prognostic value of GV after cardiac surgery.This is a single center prospective observational study in 870 consecutive cardiac surgery patients over a 3-month period at a tertiary care institute
Beena, Bansal   +6 more
openaire   +2 more sources

Postmastication digestion factors influence glycemic variability in humans

Nutrition Research, 2011
The glycemic response (GR) to food is influenced by both intrinsic and extrinsic factors. A consistent observation in GR studies is the wide within- and between-individual variations. The authors hypothesize that between-individual variations in the GR, insulin response (IR) and gastric emptying occur even when food particle size is standardized ...
Viren, Ranawana   +3 more
openaire   +2 more sources

Clinical Interpretation of Indices of Quality of Glycemic Control and Glycemic Variability

Postgraduate Medicine, 2011
The practicing physician is faced with the task of interpreting>2 dozen indices of quality of glycemic control and glycemic variability. It would be desirable to have reference data from relevant patient populations (eg, patients with the same type of diabetes, duration of diabetes, therapeutic regimen, or glycated hemoglobin [HbA1c] levels).
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