Results 211 to 220 of about 11,445 (270)

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

XoxF and the Calvin-Benson cycle mediate lanthanide-dependent growth on methanol in <i>Bradyrhizobium</i> and <i>Sinorhizobium</i>. [PDF]

Appl Environ Microbiol
Mineo CR, Jiang J, Martinez-Gomez NC.
europepmc   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle. [PDF]

Am J Transl Res
Dong Y, Fu Q, Zhang Y, Weng W, Han P, Cai Y, Sun H.   +6 more
europepmc   +1 more source

Metabolic Engineering of Ethanol Production in Thermoanaerobacter mathranii BG1 [PDF]

, 2009
Yao, Shuo
core  

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Knockout of glycerol metabolic pathways enables efficient mycolicibacterial phytosterol conversion using glycerol as cosovlent. [PDF]

Appl Microbiol Biotechnol
Song S, Wang Y, Yu J, Ma Q, Cheng X, Zhang B, Su Z.   +6 more
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion. [PDF]

J Biol Chem
Zhou Y, Baez N, Fu T, Brun T, Maechler P.   +4 more
europepmc   +1 more source

Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate. [PDF]

Proc Natl Acad Sci U S A
Cheong MC, Mackowiak B, Kim HB, Hernandez G, Nandu T, Vale K, Zhang Y, Zacharias LG, Mathews TP, Gao B, Kraus WL, Kliewer SA, Mangelsdorf DJ.   +12 more
europepmc   +1 more source