Results 141 to 150 of about 969,294 (383)

Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens [PDF]

open access: yes, 2004
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Beato, M.   +4 more
core  

Morphometric‐Assisted Prediction of Developmental Toxicity Using Stem Cell‐Based Embryo Models in Microwells

open access: yesAdvanced Healthcare Materials, EarlyView.
This proof‐of‐concept study involves high‐throughput teratogenicity screening of compounds using XEn/EpiCs, a 3D stem cell‐based embryo model, within microwells. The term ‘morphotoxicity’ is introduced to complement traditional cytotoxicity assays through automated feature extraction and machine‐learning‐assisted classification of morphologies.
Vinidhra Shankar   +4 more
wiley   +1 more source

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal‐Phenolic Networks

open access: yesAdvanced Healthcare Materials, EarlyView.
Small extracellular vesicles (sEVs) are encapsulated into protective shells composed of metal‐phenolic networks (MPNs) and secondary poly(ethylene glycol) layers. This surface modification approach enhances the storage stability of sEVs while maintaining their integrity and functionality. The shells can be selectively disassembled under mild conditions.
Chenyu Wang   +8 more
wiley   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

open access: yesAdvanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan   +3 more
wiley   +1 more source

Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes

open access: yesBrain : a journal of neurology, 2014
See Martinez-Martinez et al. (doi:10.1093/brain/awu153) for a scientific commentary on this article. Carvajal-González et al. describe the first prospective cohort of patients with glycine receptor antibodies.
A. Carvajal-González   +16 more
semanticscholar   +1 more source

The Deepest Blue: Major Advances and Challenges in Deep Blue Emitting Quasi‐2D and Nanocrystalline Perovskite LEDs

open access: yesAdvanced Materials, EarlyView.
In this review, the recent development of deep‐blue (≤465 nm) perovskite light‐emitting diodes (PeLEDs) are summarized, using different perovskite nanomaterials, including nanocrystals (NCs), quantum dots (QDs), nanoplatelets (NPLs), quasi‐2D thin film, 3D bulk thin film, as well as lead‐free perovskite nanomaterials.
Pui Kei Ko   +6 more
wiley   +1 more source

Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia

open access: yesPLoS Genetics, 2016
Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell precursors.
J. P. Fernandez-Murray   +10 more
semanticscholar   +1 more source

Conductive Polymer Coatings Control Reaction Selectivity in All‐Iron Redox Flow Batteries

open access: yesAdvanced Materials, EarlyView.
Aqueous redox flow batteries are limited by the competing hydrogen evolution reaction (HER) at their negative electrodes. In this work, conductive polymers are conformally coated on porous carbonaceous electrodes to improve the reaction selectivity of hybrid all‐iron redox flow batteries.
Emre B. Boz   +3 more
wiley   +1 more source

Glycine receptors contribute to cytoprotection of glycine in myocardial cells

open access: yesChinese Medical Journal, 2007
The classic glycine receptor (GlyR) in the central nervous system is a ligand-gated membrane-spanning ion channel. Recent studies have provided evidence for the existence of GlyR in endothelial cells, renal proximal tubular cells and most leukocytes. In contrast, no evidence for GlyR in myocardial cells has been found so far. Our recent researches have
Da-xiang Lu   +5 more
openaire   +3 more sources

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