Results 281 to 290 of about 969,294 (383)

METABOLIC CONNECTION BETWEEN PROLINE AND GLYCINE IN THE AMINO ACID UTILIZATION OF TORULOPSIS UTILIS

, 1947
G. Ehrensvärd, E. Sperber, E. Saluste, L. Reio, R. Stjernholm   +4 more
openalex   +1 more source

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

Advanced Science, EarlyView.
Polyglutamine (polyQ) tract expansion (≥ 36 amino acids) within the N‐terminal region of the Huntingtin protein (Httex1) causes Huntington's disease (HD), for which the underlying causes are not well‐understood. The authors performed computer simulations to understand the cause of HD at the molecular level.
Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal   +2 more
wiley   +1 more source

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies. [PDF]

Sci Rep
Kodate S, Sato M, Hishinuma E, Kojima K, Motoike IN, ToMMo Study Group, Koshiba S, Yamamoto M, Yamada KD, Kinoshita K.   +9 more
europepmc   +1 more source

Glycine release from astrocytes via functional reversal of GlyT1

Journal of Neurochemistry, 2017
K. Shibasaki, N. Hosoi, R. Kaneko, M. Tominaga, Katsuya Yamada   +4 more
semanticscholar   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes. [PDF]

J Intern Med
Rizo-Roca D, Henderson JD, Zierath JR.
europepmc   +1 more source

RELATIVE AMOUNT OF HEPATIC GLYCOGEN DEPOSITED BY GLUCOSE, GLYCINE, AND dl-ALANINE

, 1940
Eaton M. MacKay, Arne N. Wick, Herbert O. Carne   +2 more
openalex   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

A bioprocess optimization study to enhance the production of Menaquinone-7 using Bacillus subtilis MM26. [PDF]

Microb Cell Fact
M M, C SD.
europepmc   +1 more source

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, EarlyView.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source