Results 321 to 330 of about 969,294 (383)

Influence of powder type, power, angulation and duration in air-polishing on the surface properties of gingiva-colored composites. [PDF]

BMC Oral Health
Atagün ÖS, Kalyoncuoğlu ÜT.
europepmc   +1 more source

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source

Revealing drought tolerance strategies in pistachio clonal hybrids: role of osmotic adjustment. [PDF]

BMC Plant Biol
Osku M, Roozban MR, Sarikhani S, Arab MM, Akbari M, Vahdati K.   +5 more
europepmc   +1 more source

High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics

Advanced Science, EarlyView.
The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti, Linda Popella, Jörg Vogel, Hans M. Maric   +3 more
wiley   +1 more source

Pleiotropic neurotransmitters: neurotransmitter-receptor crosstalk regulates excitation-inhibition balance in social brain functions and pathologies. [PDF]

Front Neurosci
Chai A.
europepmc   +1 more source

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source

Regulation of mammalian cellular metabolism by endogenous cyanide production. [PDF]

Nat Metab
Zuhra K, Petrosino M, Janickova L, Petric J, Ascenção K, Vignane T, Khalaf M, Philipp TM, Ravani S, Anand A, Martins V, Santos S, Erdemir S, Malkondu S, Sitek B, Kelestemur T, Kieronska-Rudek A, Majtan T, Filgueira L, Maric D, Chlopicki S, Hoogewijs D, Haskó G, Papapetropoulos A, Logue BA, Boss GR, Filipovic MR, Szabo C.   +27 more
europepmc   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Role of metal(ii) hexacyanocobaltate(iii) surface chemistry for prebiotic peptides synthesis. [PDF]

RSC Adv
Saroha B, Kumar A, Bahadur I, Negi DS, Vats M, Kumar A, Mohammad F, Soleiman AA.   +7 more
europepmc   +1 more source

Serine metabolism in tumor progression and immunotherapy. [PDF]

Discov Oncol
Huang D, Cai H, Huang H.
europepmc   +1 more source