Results 171 to 180 of about 232,455 (292)

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

open access: yesThe FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal   +8 more
wiley   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

open access: yesThe FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero   +8 more
wiley   +1 more source

Enhancing soybean (<i>Glycine max</i> L.) yield and quality through optimized weed-free periods and sowing techniques. [PDF]

open access: yesFront Plant Sci
Arshad MA   +8 more
europepmc   +1 more source

Hairy Roadblock: Stem Trichomes Impede Herbivore Movement in a Species and Instar‐Dependent Manner

open access: yesJournal of Applied Entomology, EarlyView.
ABSTRACT Plants have evolved to deploy a vast set of defence mechanisms against insect herbivores, including physical barriers like leaf trichomes with pre and post ingestive effects. Yet, the role of stem trichomes in plant‐herbivore interactions, particularly mobility dynamics, is poorly understood.
Manish Gautam, Rupesh Kariyat
wiley   +1 more source

Genetic mapping of novel QTL for seed protein stability in food-grade soybean (Glycine max). [PDF]

open access: yesTheor Appl Genet
Mitchell AA   +9 more
europepmc   +1 more source

The GmGT‐2F, a trihelix transcription factor, regulates seed oil content by directly activating GmAGAL transcription in soybean

open access: yesJournal of Integrative Plant Biology, EarlyView.
In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li   +6 more
wiley   +1 more source

Optimizations of Cas12a‐ and Cas12i‐based adenine base editors for efficient precision editing in the plant genome

open access: yesJournal of Integrative Plant Biology, EarlyView.
A strategy coupling high‐activity nucleases with dimeric TadA‐8e optimizes plant Cas12‐based adenine base editors, boosts editing efficiency, and provides precise editors for crop breeding and genomics research.
Xiaoshuang Liu   +11 more
wiley   +1 more source

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