Results 231 to 240 of about 130,693 (343)

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Cell modeling and rescue of a novel noncoding genetic cause of glycogen storage disease IX. [PDF]

Genet Med Open
Iyengar AK, Zou X, Dai J, Francis RA, Safi A, Patterson K, Koch RL, Clarke S, Beaman MM, Mohan S, Chong JX, Bamshad MJ, Majoros WH, Rehder RC, Bali DS, Allen AS, Crawford GE, Kishnani PS, Reddy TE.   +18 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Glycogen storage disease type IX: Long-term follow-up of 52 patients from three European countries. [PDF]

Mol Genet Metab Rep
Magner M, Šáhó R, Slavíková P, Bakaľár R, Dvořáková L, Pešková K, Ramadža DP, Barić I, Ilic N, Čechová A, Řeboun M, Vlášková H, Kelifová S, Ješina P, Procházková D, Hansíková H, Honzík T, Zeman J.   +17 more
europepmc   +1 more source

Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease

The Journal of Physiology, EarlyView.
Abstract figure legend This review utilized animal models of complicated human pregnancies that result in reduced fetal nutrient or oxygen delivery, or combined nutrient and oxygen delivery, to elucidate their independent and/or synergistic contributions to the development of high‐risk cardiac phenotypes.
Melanie R. Bertossa, Jack R. T. Darby, Ashley S. Meakin, Mitchell C. Lock, Steven K. S. Cho, Christopher K. Macgowan, Mike. Seed, Michael D. Wiese, Janna L. Morrison   +8 more
wiley   +1 more source

Liver Transplantation as a Metabolic Treatment in Glycogen Storage Disease Type Ia. [PDF]

JCEM Case Rep
Atikcan Simsek DT, Avcı Dursun EM, Senay Ozcalik M, Turhan Iyidir O, Nar A, Bascil Tutuncu N.   +5 more
europepmc   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

Case Report: Perioperative Management of a Patient with Glycogen Storage Disease Type IXd. [PDF]

Surg Case Rep
Kawata K, Otsu H, Hu Q, Tsuda Y, Nagao Y, Yonemura Y, Masuda T, Yoshizumi T, Mimori K.   +8 more
europepmc   +1 more source

Molecular diagnosis of glycogen storage disease and disorders with overlapping clinical symptoms by massive parallel sequencing

Genetics in Medicine, 2016
A. Vega, C. Medrano, R. Navarrete, L. Desviat, B. Merinero, P. Rodríguez-Pombo, I. Vitoria, M. Ugarte, C. Pérez‐Cerdá, B. Pérez   +9 more
semanticscholar   +1 more source

Glucose and fructose contributions to exogenous carbohydrate oxidation and performance at moderate altitude

The Journal of Physiology, EarlyView.
Abstract figure legend Co‐ingesting fructose with glucose increases exogenous carbohydrate oxidation at sea level, but its effect at altitude is unclear. This study compared glucose–fructose (GLU–FRU), glucose alone (GLU) and placebo during 120 min of running at 70% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}{\mathrm{max}}}}$ at 2500 m in eight males.
Nicola C. Arjomandkhah, Andy J. King, Alex Griffiths, Roderick F. G. J. King, Douglas, J. Morrison, Thomas Preston, John P. O'Hara   +7 more
wiley   +1 more source