Results 191 to 200 of about 17,404,319 (246)

Hypoglycemic Effect of Astaxanthin Oil–Fish Oil Complex in Mice With Type 2 Diabetes

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This study demonstrates that an astaxanthin oil–fish oil complex exerts synergistic hypoglycemic and hepatoprotective effects. It enhances glucose metabolism and relieves oxidative stress in insulin‐resistant HepG2 cells. In high‐fat diet mice, the complex reduces hyperglycemia, improves lipid profiles, and attenuates hepatic steatosis and pancreatic ...
Zhichao Lin, Jianlin He, Xiaomin Xi, Yiping Zhang, Qingqing Le, Yaqi Guo, Hua Fang, Wenhui Jin, Hui Chen, Sijin Chen, Weizhu Chen   +10 more
wiley   +1 more source

Intramuscular Fat as a Biomarker of Muscle Health: Strengths, Limitations and Open Challenges

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Intramuscular fat (IMF), also known as myosteatosis, refers to the accumulation of lipids within and around skeletal muscle fibres. Excess IMF is increasingly recognised as a sign of poor muscle quality, linked to reductions in strength, power and mobility, and associated with adverse outcomes in metabolic disease, osteoarthritis ...
Christopher Spence, Martin Alberto Belzunce, Anna Di Laura, Johann Henckel, Alister J. Hart   +4 more
wiley   +1 more source

Obesity from the perspective of the liver. [PDF]

Pathol Oncol Res
Csala M, Mandl J.
europepmc   +1 more source

Preparing Genetic Counselors for Advocacy Partnerships: A Novel Internship Model

Journal of Genetic Counseling, Volume 35, Issue 5, October 2026.
ABSTRACT Patient advocacy organizations (PAOs) and genetic counseling have expanded in tandem with the growth of precision medicine. Genetic counseling and PAOs share important goals related to advancing genomic medicine, creating novel possibilities for synergistic collaboration, especially as the sheer number of PAOs focused on genetic conditions ...
Marin Kalista, Lisa Jay Kessler, Deborah Requesens, Kathleen D. Valverde, Rebecca Mueller   +4 more
wiley   +1 more source

RNA sequencing resolves a novel noncanonical splice-region variant in <i>PHKA2</i> causing glycogen storage disease type IX α2: a case report. [PDF]

Transl Pediatr
Chen F, He J, Cheng H, Shu S.
europepmc   +1 more source

Sustainable Overproduction of the Bacterial Pigment Indigoidine as a Natural Colorant: Stability Evaluation, Inhibition of Obesity‐Diabetes‐Related Digestive Enzymes, and Activation of AMPK–AKT

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Production of indigoidine (IND) increased from 1.04 to 2.76 g/L using an optimized LB medium composed of glucose, l‐glutamine, tryptone, yeast extract, MgSO4·7H2O, and KH2PO4. The IND has significant inhibition properties against amylase and lipase enzymes, stimulates AMPK and AKT pathways, and improves glucose uptake.
Tahani Ali Asseri
wiley   +1 more source

Metabolomic Insights into Lysosomal Storage Diseases: An Untargeted View. [PDF]

Metabolites
Di Carlo G, Tommolini ML, Frisco A, Spalluto G, Foley D, Zucchelli M, Cufaro MC, Cicalini I, Bucci I, Federici L, De Laurenzi V, Pieragostino D, Rossi C.   +12 more
europepmc   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

Guidelines for home-based enzyme replacement therapy in children and adolescents with mucopolysaccharidosis: a scoping review. [PDF]

Rev Esc Enferm USP
Oliveira VR, Xavier BLQ, Felipe CVS, Alencar IGM, Silva HLLD, Souza FMLC, Oliveira JSA.   +6 more
europepmc   +1 more source