Results 231 to 240 of about 422,950 (380)

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source

Abnormal metabolic networks participate in invasion and migration of tumors of the digestive system (Review). [PDF]

Oncol Lett
Li J, Zhang W.
europepmc   +1 more source

Some Effects of Artificial Media upon Glycolysis in Rat Platelets [PDF]

, 1967
Ennio C. Rossi, Edith Volk
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis. [PDF]

BMC Complement Med Ther
Shi R, Liu MQ, Xiao JP, Zhu YK, Zhu JX, Zhao WM, Wang ZJ, Zhu YY, Li XL, Wang XR, Wang RF, Wang DG.   +11 more
europepmc   +1 more source

THE MECHANISM BY WHICH GLYCERALDEHYDE INHIBITS GLYCOLYSIS

, 1950
Henry A. Lardy, Virgil D. Wiebelhaus, Kingsley M. Mann   +2 more
openalex   +1 more source

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Science, 2018
M. Kornberg, P. Bhargava, Paul M. Kim, V. Putluri, A. Snowman, N. Putluri, P. Calabresi, S. Snyder   +7 more
semanticscholar   +1 more source

HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming

Advanced Science, EarlyView.
In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou, Ling‐Feng Gu, Yi‐Xi Chen, Peng Jing, Tong‐Tong Yang, Ye He, Yu‐Lin Bao, Xiang‐Zheng Zhang, Chong Du, Si‐Bo Wang, Tian‐Kai Shan, Jia‐Yi Chen, Hao Wang, Qi‐Ming Wang, Li‐Ping Xie, Yang Zhao, Yong Ji, Lian‐Sheng Wang   +17 more
wiley   +1 more source

Network pharmacology and experimental study on the inhibition of glycolysis by amentoflavone in pancreatic cancer. [PDF]

Discov Oncol
He X, Chen P, Zhao Z, Choe H, Ali T, Ding K, Wu X, Ma J, Zhang L.   +8 more
europepmc   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source