Results 231 to 240 of about 226,351 (284)

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity. [PDF]

J Tissue Eng Regen Med
Che J, Qiu Z, Hou H, Li Y, He L, Sun J, Zhang S, Li M, Pan S, Zhang W, Niu Y.   +10 more
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification. [PDF]

Noncoding RNA Res
Chen S, Xia H, Chen S.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Exosomal miR-3126-5p derived from cancer-associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis. [PDF]

Clin Transl Med
Zhang Z, Ma H, Zheng Y, Wang L, Wang C, Liu Y, Lu H, Wang S.   +7 more
europepmc   +1 more source

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

Decoding TREM2 Signaling Pathways: Linking Macrophage Glycolysis to Inflammatory Diseases in the CNS. [PDF]

Neurol Neuroimmunol Neuroinflamm
Che Y, Yu Z, Ji S, Yang D.
europepmc   +1 more source

Figure S4 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

Takuma Uo, Kayode K. Ojo, Cynthia C.T. Sprenger, Kathryn S. Epilepsia, B. Gayani K. Perera, Mamatha Damodarasamy, Shihua Sun, Soojin Kim, Hannah H. Hogan, Matthew A. Hulverson, Ryan Choi, Grant R. Whitman, Lynn K. Barrett, Samantha A. Michaels, Linda H. Xu, Vicky L. Sun, Samuel L.M. Arnold, Haley J. Pang, Matthew M. Nguyen, Anna-Lena B.G. Vigil, Varun Kamat, Lucas B. Sullivan, Ian R. Sweet, Ram Vidadala, Dustin J. Maly, Wesley C. Van Voorhis, Stephen R. Plymate   +26 more
openalex   +1 more source

Giardiavirus rewires host translation and glycolytic metabolism to support its replication in <i>Giardia duodenalis</i>. [PDF]

Virulence
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P.   +12 more
europepmc   +1 more source