Results 271 to 280 of about 367,476 (333)

Exploring the Glycolytic Mechanisms in "Driver Gene-Negative" Lung Adenocarcinoma (LUAD): A Single-Cell RNA Sequencing Approach to Identify the MIF-HIF-1α Axis. [PDF]

J Cancer
Yang HS, Li YH, Chen Q, Luo HH, Yu QD, Han Y, Zhu W, Zhang J, Liang CY.   +8 more
europepmc   +1 more source

A novel lncRNA RP11-544M22.13 enhances glycolysis-induced cisplatin resistance in non-small cell lung cancer

Jun Xiong, Haiyue Zhang, Zhou Pan, Yixuan Wang, Hui Chen, Mei Yang   +5 more
openalex   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Glycolytic reprogramming during microglial polarization in neurological diseases. [PDF]

Front Immunol
Li X, Fang C, Li Y, Xiong X, Xu X, Gu L.
europepmc   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

TKT drives renal cell carcinoma progression through metabolic reprogramming and synergistic interaction with PKM2. [PDF]

Cell Death Discov
Wang Q, Tang A, Zhuang Q, Xu H, Xu S, Zhang J, Wang Y, Li L, Chu S, Wang Y, Bai J, Li M, Zhang R.   +12 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

TRIM8-dependent K63-ubiquitinated PGK1 promotes glycolysis and angiogenesis in gastric cancer via interaction with ACAT1. [PDF]

Cell Death Dis
Feng A, Zhang J, Wang Z, Chen Z, Fang K, Li Z, Jiang H, Leng Z, Zhang S, Chu Y, Lian J, Chen T, Ye L, Xu M, He L.   +14 more
europepmc   +1 more source

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo, Kunzhao Huang, Xiaoyuan Yi, Pei Lu, Huaying Xie, Wen Li, Qingyu Zeng, Feifei He, Duo Wang, Liyan Wang   +9 more
wiley   +1 more source

Cigarette Smoking-Induced Glucose Metabolic Reprogramming in Chronic Obstructive Pulmonary Disease: Mechanisms and Therapeutic Implications. [PDF]

Int J Chron Obstruct Pulmon Dis
Ji T, Gu YY, Gao YM, Xie Y, Liu Z, Cheng A, Zhou X, Ailifeire A, Wang M, Song Q, Shi Y, Shi S, He J, Zhao L, Xiao D, Wang C.   +15 more
europepmc   +1 more source