Results 281 to 290 of about 367,476 (333)

Puerarin Targets MIC19 to Suppress Mitochondrial Metabolism of Tumor‐Infiltrating Tregs and Enhance Anti‐tumor Immunity

Advanced Science, EarlyView.
Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li, Ziyan Song, Jianjun Ding, Yiheng Zhou, Tianning Huang, Qufei Qian, Miao Yu, Wenzhao Chen, Jiazheng Liu, Ling Lu, Qiuyang Chen   +10 more
wiley   +1 more source

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

Advanced Science, EarlyView.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang, Chunyu Du, Guanyu Zheng, Dahu Ding   +3 more
wiley   +1 more source

Acetylbinankadsurin A Decreases Macrophage Glycolysis and Pro-Inflammatory Phenotype Polarization via Inhibiting HIF-1α to Alleviate Hepatic Fibrosis in Mice. [PDF]

Molecules
Yao Q, Peng W, Lu H, Yang Y, Rao Z, Xie X, Huang D, Wang W, Yan J, Liu J.   +9 more
europepmc   +1 more source

Figure S2 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

Takuma Uo, Kayode K. Ojo, Cynthia C.T. Sprenger, Kathryn S. Epilepsia, B. Gayani K. Perera, Mamatha Damodarasamy, Shihua Sun, Soojin Kim, Hannah H. Hogan, Matthew A. Hulverson, Ryan Choi, Grant R. Whitman, Lynn K. Barrett, Samantha A. Michaels, Linda H. Xu, Vicky L. Sun, Samuel L.M. Arnold, Haley J. Pang, Matthew M. Nguyen, Anna-Lena B.G. Vigil, Varun Kamat, Lucas B. Sullivan, Ian R. Sweet, Ram Vidadala, Dustin J. Maly, Wesley C. Van Voorhis, Stephen R. Plymate   +26 more
openalex   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

LINC02159 modulated the glycolysis and proliferation of TNBC cell via targeting miR-1285-3p/G6PI axis. [PDF]

Sci Rep
Zhao X, Zheng R, Wu X, Hao Y, Xie Q, Bai X.   +5 more
europepmc   +1 more source

Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

Siying Zeng, Yuqi Wang, Minfeng Ying, Chengmeng Jin, Chang Ying, Di Wang, Hao Wu, Xun Hu   +7 more
openalex   +1 more source

Persistent metabolic youth in the aging female brain [PDF]

, 2019
Bateman, Randall J., Benzinger, Tammie L.-S., Blazey, Tyler M., Couture, Lars E., Durbin, Tony J., Goyal, Manu S., Morris, John C., Raichle, Marcus E., Su, Yi, Vlassenko, Andrei G.   +9 more
core   +1 more source

Mendelian randomization with proxy exposures: challenges and opportunities. [PDF]

Genetics
Rahu I, Tambets R, Fauman EB, Alasoo K.
europepmc   +1 more source