Influences of metabolism and lipid homeostasis on regulatory vs. conventional T cells and implications for autoimmunity. [PDF]
Nguyen MA, Lee SS, Walsh CM.
europepmc +1 more source
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang+13 more
wiley +1 more source
Sympathetic nervous system in tumor progression and metabolic regulation: mechanisms and clinical potential. [PDF]
Sun C, Shen Y, Wang F, Lu T, Zhang J.
europepmc +1 more source
Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine
A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li+8 more
wiley +1 more source
Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies. [PDF]
Wang R+6 more
europepmc +1 more source
Factors That Control the Effect of pH on Glycolysis in Leukocytes
M. L. Halperin+3 more
openalex +1 more source
Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
Min Peng+5 more
semanticscholar +1 more source
Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen+7 more
wiley +1 more source
Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome. [PDF]
Zhu R, Yu X, Li Y.
europepmc +1 more source