Results 71 to 80 of about 15,705 (221)

An ImmunoPEGliposome for Targeted Antimalarial Combination Therapy at the Nanoscale

Pharmaceutics, 2019
Combination therapies, where two drugs acting through different mechanisms are administered simultaneously, are one of the most efficient approaches currently used to treat malaria infections.
Arnau Biosca, Lorin Dirscherl, Ernest Moles, Santiago Imperial, Xavier Fernàndez-Busquets   +4 more
doaj   +1 more source

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia [PDF]

, 2009
Background: The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also those younger patients who relapse, remain dismal and novel therapies are urgently ...
Alessia Lodi, Chris M. Bunce, Farhat L. Khanim, Heinrich Schrewe, Jane Birtwistle, Jim A. Murray, Joanne C. Mountford, Jon P. Ride, Mark R. Viant, Mark T. Drayson, Michael Goodyear, Nicholas J. Davies, Rachel E. Hayden, Richard M. Green, Stefano Tiziani, Ulrich L. Gunther   +15 more
core   +5 more sources

MMS22L is a novel key actor of normal and pathological erythropoiesis

HemaSphere, Volume 9, Issue 12, December 2025.
Abstract The emergence of next‐generation sequencing techniques has led to the genetic characterization of numerous congenital erythroid disorders, emphasizing crucial pathways in both normal and pathological erythropoiesis. In this study, whole exome sequencing of a single patient with atypical congenital pure red cell aplasia revealed a mutation in ...
Elia Colin, Ivan Ferrer‐Vicens, Dror Brook, Mohammad Salma, Charlotte Andrieu‐Soler, Elisa Bayard, Alicia Fernandes, Chantal Brouzes, Carine Lefèvre, Romain Duval, Michaël Dussiot, Thiago Trovati, Geneviève Courtois, Slim Azouzi, Mohammed Zarhrate, Anne Lambilliotte, Sophie Park, Benjamin Carpentier, Martin Colard, Sandra Manceau, Despina Moshous, Patrick Mayeux, Emilie‐Fleur Gautier, Annarita Miccio, Jean Soulier, William Vainchenker, Liran Shlush, Lydie Da Costa, Jan Frayne, Eric Soler, Olivier Hermine, Lucile Couronné   +31 more
wiley   +1 more source

Population genetics of GYPB and association study between GYPB*S/s polymorphism and susceptibility to P. falciparum infection in the Brazilian Amazon. [PDF]

PLoS ONE, 2011
Merozoites of Plasmodium falciparum invade through several pathways using different RBC receptors. Field isolates appear to use a greater variability of these receptors than laboratory isolates.
Eduardo Tarazona-Santos, Lilian Castilho, Daphne R T Amaral, Daiane C Costa, Natália G Furlani, Luciana W Zuccherato, Moara Machado, Marion E Reid, Mariano G Zalis, Andréa R Rossit, Sidney E B Santos, Ricardo L Machado, Sara Lustigman   +12 more
doaj   +1 more source

Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia. [PDF]

, 2017
Acquired elliptocytosis is a known but rarely described abnormality in the myelodysplastic syndromes (MDS). Here we report the case of an elderly male who was admitted to the hospital with chest pain, dyspnea, and fatigue and was found to be anemic with ...
Dwyre, Denis M, Jonas, Brian A, Kjelland, Jacob D   +2 more
core   +2 more sources

Glycophorin B and glycophorin E genes arose from the glycophorin A ancestral gene via two duplications during primate evolution.

Journal of Biological Chemistry, 1993
Human glycophorin A, B, and E genes are homologous from the 5'-flanking region to 1 kilobase downstream from the exon encoding the transmembrane region. Analysis of human Alu sequences at the transition site from the homologous to nonhomologous region suggested that the GPA gene most closely resembles the ancestral gene, whereas GPB and GPE genes arose
A, Rearden, A, Magnet, S, Kudo, M, Fukuda   +3 more
openaire   +2 more sources

GDF15 Ameliorates Deoxynivalenol‐Induced Anemia by Resolving Ribosomal Stress–Mediated Erythropoietic Arrest

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Deoxynivalenol induces anemia by disrupting hematopoietic homeostasis and impairing erythroid lineage commitment and differentiation via ribosomal stress–mediated G1/S cell cycle arrest. GDF15 supplementation alleviates this arrest through the β‐catenin–Myc–p21 signaling axis, highlighting GDF15 as a potential therapeutic target for DON‐induced ...
Yan Li, Peijun Jia, Jingxin Zhang, Huan Zhang, Bing Li, Jiawei Chang, Yating Li, Longzhen Zhao, Yazhe Zhen, Tingting Zheng, Yuanlin Xu, Xiuli An, Shijie Zhang   +12 more
wiley   +1 more source

Erythrocyte binding peptides: a story in the search for a malaria vaccine [PDF]

Exploration of Drug Science
Merozoite invasion of erythrocytes relies on molecular interactions between parasite and host proteins, making these proteins potential therapeutic targets.
Mauricio Urquiza-Martinez, Daniela Benavides-Rubio, Fanny Guzmán-Quimbayo   +2 more
doaj   +1 more source

Dynamics of the Glycophorin A Dimer in Membranes of Native-Like Composition Uncovered by Coarse-Grained Molecular Dynamics Simulations. [PDF]

PLoS ONE, 2015
Membranes are central for cells as borders to the environment or intracellular organelle definition. They are composed of and harbor different molecules like various lipid species and sterols, and they are generally crowded with proteins.
Nadine Flinner, Enrico Schleiff
doaj   +1 more source

Granulocytic sarcoma (chloroma) of the oral cavity: Report of a case and literature review [PDF]

, 2003
SummaryA case of granulocytic sarcoma (chloroma) of the palatal mucosa is reported. Granulocytic sarcomas are composed of a localized collection of immature myeloid cells and are considered to be specific lesions of AML or the onset of a blast crisis in ...
M.J. Koudstaal, K.G.H. van der Wal, K.H. Lam, C.A. Meeuwis, L. Speleman, M.D. Levin, Bassichis, Cukier, Tong, Neville, Eisenberg, Ficarra, Rodriguez, Burns, King, Muss, Yamauchi, Lee, Dock, Lui, Castella, Knowles, Bain, Roth, Duffy, Michaud, Reichart, Wendell Todd, Zappia, Almadori, Eser, Sood, Chiari, Brooks, Neiman, Hansen, Conran, Takagi, Welch, Timmis, Muller, Saleh, Dreizen, Ferguson, Barker, Alessi, Cho, Stack, Ritter, Tuset, Wiernik, Lynch, Tomás Carmona, Amin, Jordan, Asna   +55 more
core   +1 more source