Structural variation of the malaria-associated human glycophorin A-B-E region
BMC Genomics, 2020 Background Approximately 5% of the human genome shows common structural variation, which is enriched for genes involved in the immune response and cell-cell interactions. A well-established region of extensive structural variation is the glycophorin gene
Sandra Louzada +13 more
doaj +2 more sources
Brown Recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure. [PDF]
PLoS ONE, 2013 The venom of Loxosceles reclusa (Brown Recluse spider) can cause a severe, life-threatening hemolysis in humans for which no therapy is currently available in the USA beyond supportive measures.
Eric A Gehrie, Hui Nian, Pampee P Young
doaj +2 more sources
Critical glycosylated residues in exon three of erythrocyte Glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity [PDF]
mBio, 2014 Erythrocyte invasion is an essential step in the pathogenesis of malaria. The erythrocyte binding-like (EBL) family of Plasmodium falciparum proteins recognizes glycophorins (Gp) on erythrocytes and plays a critical role in attachment during invasion ...
Paing, May M +2 more
core +4 more sources
Diffusion of glycophorin A in human erythrocytes.
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016 Several lines of evidence suggest that glycophorin A (GPA) interacts with band 3 in human erythrocyte membranes including: i) the existence of an epitope shared between band 3 and GPA in the Wright b blood group antigen, ii) the fact that antibodies to GPA inhibit the diffusion of band 3, iii) the observation that expression of GPA facilitates ...
Katie M Giger +3 more
semanticscholar +3 more sources
The Baculovirus-Expressed Binding Region of Plasmodium falciparum EBA-140 Ligand and Its Glycophorin C Binding Specificity [PDF]
PLoS ONE, 2015 The erythrocyte binding ligand 140 (EBA-140) is a member of the Plasmodium falciparum DBL family of erythrocyte binding proteins, which are considered as prospective candidates for malaria vaccine development.
Radoslaw Kaczmarek +2 more
exaly +2 more sources
Journal of Biological Chemistry, 2013 Background: The GYPA-PfEBA175 interaction is important for erythrocyte invasion by the malaria parasite. Results: The entire ectodomain of EBA175 interacted with GYPA with different biochemical parameters to the previously determined GYPA-binding ...
Steven J Johnson +2 more
exaly +2 more sources
Host-pathogen interactions involved in erythrocyte invasion by Francisella tularensis [PDF]
Frontiers in Cellular and Infection MicrobiologyFrancisella tularensis is a gram negative, facultative intracellular bacterium that causes the zoonotic disease tularemia. F. tularensis is capable of invading mammalian erythrocytes, a phenomenon that enhances colonization of ticks following a blood ...
Rori M. Schreiber +6 more
doaj +2 more sources
Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A. [PDF]
Proceedings of the National Academy of Sciences, 1987 Here we describe the isolation and nucleotide sequence of a human glycophorin B cDNA. The cDNA was identified by differential hybridization of synthetic oligonucleotide probes to a human erythroleukemic cell line (K562) cDNA library constructed in phage vector lambda gt10.
P. Siebert, M. Fukuda
semanticscholar +3 more sources
Lipid-mediated interactions tune the association of glycophorin A helix and its disruptive mutants in membranes [PDF]
Physical Chemistry, Chemical Physics - PCCP, 2010 The specific and non-specific driving forces of helix association within membranes are still poorly understood. Here, we use coarse-grain molecular dynamics simulations to study the association behavior of glycophorin A and two disruptive mutants, T87F ...
Marrink, Siewert J., Sengupta, Durba
core +3 more sources
Perls' Prussian blue staining and chemistry of Prussian blue and Turnbull blue [PDF]
Forensic Science International: SynergyPerls’ Prussian blue staining or reaction is used to detect haemosiderin, which is stored or sequestrated non-haeme iron. Methodologically, the iron in haemosiderin is released as Fe3+ (FeIII) by hydrochloric acid (HCl), and FeIII reacts with potassium ...
Ai Sonoda +4 more
doaj +2 more sources