Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.
PLoS ONE, 2021 Low plasma levels of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) are associated with decreased low-density lipoprotein (LDL) cholesterol and a reduced risk of cardiovascular disease.
Rhogerry Deshycka +8 more
doaj +2 more sources
KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]
, 2009 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny +4 more
core +1 more source
Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging
Blood Advances, 2018 : Lutheran/basal cell adhesion molecule (Lu/BCAM) is a transmembrane adhesion molecule expressed by erythrocytes and endothelial cells that can interact with the extracellular matrix protein laminin-α5.
T.R.L. Klei +12 more
doaj +1 more source
Detection of microparticles from human red blood cells by multiparametric flow cytometry [PDF]
, 2015 Background: During storage, red blood cells (RBC) undergo chemical and biochemical changes referred to as "storage lesions". These events determine the loss of RBC integrity, resulting in lysis and release of microparticles.
CORDOVA, NICOLETTA +11 more
core +1 more source
An epidemiologic study of early biologic effects of benzene in Chinese workers. [PDF]
, 1996 Benzene is a recognized hematotoxin and leukemogen, but its mechanisms of action in humans are still uncertain. To provide insight into these processes, we carried out a cross-sectional study of 44 healthy workers currently exposed to benzene (median 8 ...
Bechtold, WE +20 more
core +2 more sources
Hematology Reports, 2018 Acute monoblastic leukemia (AMoL) is characterized by cells with highly undifferentiated morphology. Cytochemistry with non-specific esterases is negative in up to 20% of cases. Immunophenotyping by flow cytometry has an essential role in diagnosing such
Giovanni Carulli +8 more
doaj +1 more source
Haematologica, 2009 Background Protein 4.1R is an important component of the red cell membrane skeleton. It imparts structural integrity and has transmembrane signaling roles by direct interactions with transmembrane proteins and other membrane skeletal components, notably ...
Kris P. Jeremy +9 more
doaj +1 more source
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +8 more
core +2 more sources
Multimeric assembly of host-pathogen adhesion complexes involved in apicomplexan invasion [PDF]
, 2014 Disrupting erythrocyte invasion by Plasmodium falciparum is an attractive approach to combat malaria. P. falciparum EBA-175 (PfEBA-175) engages the host receptor Glycophorin A (GpA) during invasion and is a leading vaccine candidate.
Paing, May M, Tolia, Niraj H
core +8 more sources
Erythrocyte glycophorins as receptors for Plasmodium merozoites
Parasites & Vectors, 2019 Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes. In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in the invasion of red blood cells (RBCs) by malaria parasites, which ...
Ewa Jaskiewicz +3 more
doaj +1 more source