Results 71 to 80 of about 21,169,060 (256)

Human Glycophorin A: Aspects of Glycosylation.

Trends in Glycoscience and Glycotechnology, 1994
グリコホリンA(GPA)は35kDaの糖タンパクで、ヒト赤血球上のシアリル化糖タンパクの中で最も豊富なものである(～0.2-1x106分子/赤血球)(1)。これは全配列が決定された最初の膜タンパクで131個のアミノ酸よりなり、今でも一度膜を貫通する型の膜タンパクの中で最も良く研究されたものの一つである(2、3)。GPAが糖化学者を惹き付けるのは、その細胞外ドメインに多くのグリコシドを持ちシアル酸含量が異常に高いためである(4-9)。ヒト赤血球グリコホリンのGPA遺伝子解析やその多型(10)、GPA抗原の構造と機能(1)に関する総説が最近いくつか出ている。本総説ではGPAのグリコシル化やグリコシル化サイト、GPAやその多型に存在する糖鎖の型 ...
Andrew A. Gooley, Anthony Pisano, Keith L. Williams   +2 more
openaire   +2 more sources

Rps19R67∆ mutation creates a model of Diamond–Blackfan anemia and reveals downstream mediators of p53 pathway

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Diamond–Blackfan anemia (DBA) is a rare bone marrow failure syndrome accompanied by cardiovascular, skeletal, and urogenital abnormalities. Most of the affected individuals carry mutations in ribosomal proteins, including RPS19, a component of the 40S ribosomal subunit.
Juraj Kokavec, Tereza Turková, Björn Schuster, Jan Prochazka, František Spoutil, Kristína Jamrichová, Markéta Holečková, Karel Chalupský, Inken M. Beck, Jesús Ruberte, Matilde Vale, Lukáš Čermák, Tomáš Stopka, Radislav Sedlacek   +13 more
wiley   +1 more source

Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation [PDF]

, 2014
YesRecombinant human erythropoietin (rHuEPO) is an effective treatment for anaemia but concerns that it causes disease progression in cancer patients by activation of EPO receptors (EPOR) in tumour tissue have been contro- versial and have restricted
Abramsson, Anagnostou, Arcasoy, Brown, Broxmeyer, Caro, Elliott, Elliott, Ghezzi, Graham, Gross, Henke, Hill, Jelkmann, Katz, Lappin, Leyland-Jones, Liang, Lifshitz, Mausberg, Miller, Mittelman, Nairz, Oster, Provatopoulou, Prutchi-Sagiv, Prutchi-Sagiv, Rizzo, Smith, Stasko, Trincavelli, Vogel, Wenger, Xue   +33 more
core   +1 more source

Suppression of RBC alloimmunization and regulation of CD4+T cell dependence by C3 is not due to genetic confounders in mice

Transfusion, Volume 66, Issue 1, Page 178-186, January 2026.
Abstract Background Activation of complement protein C3 generally enhances antibody responses and C3‐null mice have decreased antibody‐based immunity. Mener et al. have reported a paradoxical suppressor function for C3 in alloimmunization to transfused RBCs as alloantibodies are increased in C3‐null mice.
Arijita Jash, Ariel Hay, James C. Zimring   +2 more
wiley   +1 more source

Chondrogenic potential of human articular chondrocytes and skeletal stem cells: a comparative study

, 2014
Regenerative medicine strategies have increasingly focused on skeletal stem cells (SSCs), in response to concerns such as donor site morbidity, dedifferentiation and limited lifespan associated with the use of articular chondrocytes for cartilage repair.
Li, Siwei, Oreffo, Richard O.C., Sengers, Bram G., Tare, Rahul S.   +3 more
core   +1 more source

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. [PDF]

, 2012
Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Bosman, GJ, Brock, R, Cluitmans, JC, Dinkla, S, Fransen, J, Fuchs, B, Joosten, I, Schiller, J, Tomelleri, C, Verdurmen, WP, Wessels, K   +10 more
core   +1 more source

Flow cytometric characterization of normal and variant cells with monoclonal antibodies specific for glycophorin A.

Journal of Immunology, 1985
Quantitative immunofluorescence measurements were performed on erythrocytes labeled with monoclonal antibodies to glycophorin A (GPA) to assess the level of binding of these antibodies to normal and variant cell types.
R. Langlois, W. Bigbee, R. Jensen
semanticscholar   +1 more source

Risks for human health related to the presence of plant lectins in food

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The European Commission asked the European Food Safety Authority (EFSA) to assess the risk related to the presence of plant lectins in food. Based on the available evidence, the CONTAM Panel considered only phytohaemagglutinin (PHA), a legume lectin from beans (Phaseolus sp.), for the risk characterisation.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Hanne Frøkiær, Bettina Grasl‐Kraupp, Patrick Mulder, Pierre Rougé, Heather Wallace, Marios Georgiadis, José Ángel Gómez Ruiz, Eirini Kouloura, Olaf Mosbach‐Schulz, Lydia Alarcón Asensio, Eleni Gkimprixi, Evangelia Ntzani   +30 more
wiley   +1 more source

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia [PDF]

, 2009
Background: The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also those younger patients who relapse, remain dismal and novel therapies are urgently ...
Alessia Lodi, Chris M. Bunce, Farhat L. Khanim, Heinrich Schrewe, Jane Birtwistle, Jim A. Murray, Joanne C. Mountford, Jon P. Ride, Mark R. Viant, Mark T. Drayson, Michael Goodyear, Nicholas J. Davies, Rachel E. Hayden, Richard M. Green, Stefano Tiziani, Ulrich L. Gunther   +15 more
core   +5 more sources

Glycophorin SAT of the human erythrocyte membrane is specified by a hybrid gene reciprocal to glycophorin Dantu gene [PDF]

Blood, 1995
Previous studies of two unrelated Japanese families showed that two isoforms of glycophorin were associated with the expression of SAT antigen on the erythrocyte membrane. Here we report the molecular basis for one form of this MNSs-related surface marker that displayed an altered immunoblotting pattern.
C H, Huang, M E, Reid, Y, Okubo, G L, Daniels, O O, Blumenfeld   +4 more
openaire   +2 more sources