Results 91 to 100 of about 1,005,229 (334)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Multivalent MVA-vectored vaccine elicits EBV neutralizing antibodies in rhesus macaques that reduce EBV infection in humanized mice

Frontiers in Immunology
IntroductionEpstein-Barr virus (EBV) is an oncogenic human herpesvirus associated with ~350,000 cases of lymphoid and epithelial malignancies every year, and is etiologically linked to infectious mononucleosis and multiple sclerosis. Despite four decades
Gabriela M. Escalante, Ivana G. Reidel, Lorraine Z. Mutsvunguma, Simeon Cua, Brenda A. Tello, Esther Rodriguez, Esther Rodriguez, Mafalda A. Farelo, Cloe Zimmerman, Cloe Zimmerman, Murali Muniraju, He Li, Aparna N. Govindan, Michael K. Axthelm, Michael K. Axthelm, Scott W. Wong, Scott W. Wong, Scott W. Wong, Javier Gordon Ogembo   +18 more
doaj   +1 more source

Lactoferrin: a review

Veterinární Medicína, 2008
This review discusses the biological properties of the glycoprotein lactoferrin. Lactoferrin has been identified in secretions from exocrine glands and in specific granules of neutrophils.
L. Adlerova, A. Bartoskova, M. Faldyna
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

A Long-Wavelength Fluorescent Squarylium Cyanine Dye Possessing Boronic Acid for Sensing Monosaccharides and Glycoproteins with High Enhancement in Aqueous Solution

Sensors, 2012
Fluorescence sensing of saccharides and glycoproteins using a boronic acid functionalized squarylium cyanine dye (“<strong>SQ-BA</strong>”) is characterized in terms of synthetic, fluorometric, thermodynamic and kinetic parameters.
Hiroyuki Nakazumi, Christa L. Colyer, Takeshi Maeda, Tara L. Massie, Shingo Saito   +4 more
doaj   +1 more source

Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]

, 2019
We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey, Komives, Elizabeth A, Kopcho, Noah   +2 more
core   +1 more source

Influence of anticardiolipin and anti-β2 glycoprotein I antibody cutoff values on antiphospholipid syndrome classification [PDF]

, 2019
Background: Anticardiolipin (aCL) and anti-beta 2 glycoprotein I (a beta 2GPI) immunoglobulin (Ig) G/IgM antibodies are 2 of the 3 laboratory criteria for classification of antiphospholipid syndrome (APS).
de Laat, Bas, Devreese, Katrien, Kelchtermans, Hilde, Musial, Jacek, Vanoverschelde, Laura   +4 more
core   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Contribution to the biochemical characterization of the silk and structure characterization of the cocoons of the horse chestnut leaf miner Cameraria ohridella (Lepidoptera: Gracillariidae)

European Journal of Entomology, 2011
This study of the proteins in the silk of the summer and winter cocoons of the horse chestnut leaf miner Cameraria ohridella revealed they can inhibit protease activity.
Veronika HNĚVSOVÁ, Dalibor KODRÍK, František WEYDA   +2 more
doaj   +1 more source

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source