Results 71 to 80 of about 929,134 (307)

Analytical Technologies for Identification and Characterization of the Plant N-Glycoproteome

Frontiers in Plant Science, 2012
N-glycosylation is one of the most common and complex post-translational modifications of eukaryotic proteins and one that has numerous roles, such as modulating protein stability, sorting, folding, enzyme activity and ligand interactions. In plants, the
Eliel eRuiz-May, Theodore William Thannhauser, Sheng eZhang, Jocelyn Kenneth Campbell Rose   +3 more
doaj   +1 more source

Carcinoembryonic Antigen Gene Family [PDF]

, 1991
The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons.
Accili, Ahnen, Anderson, Arakawa, Arakawa, Audette, Aurivillius, Barnett, Barnett, Barnett, Barnett, Barnett, Barthels, Beatty, Beauchemin, Beauchemin, Beauchemin, Beidler, Benchimol, Berling, Berling, Bhattacharya-Chatterjee, Biggin, Bischof, Bischoff-Delaloye, Bohn, Bordes, Borjigin, Boucher, Boucher, Buchegger, Buchegger, Burtin, Börmer, Capecchi, Chakrabarty, Chakrabarty, Chan, Chan, Chandrasekaran, Chou, Chou, Chu, Cordon, Cournoyer, Cross, Cunningham, DeRobertis, Dustin, Edelman, Edwards, Egan, Fantini, Feizi, Fiebig, Freyer, Fritsch, Fritsche, Fritz Grunert, Gold, Gold, Goldenberg, Goldenberg, Greiner, Greiner, Grosveld, Grunert, Grunert, Guadagni, Hager, Hammarström, Haniford, Hansson, Hardman, Hass, Hefta, Hefta, Hefta, Hemperly, Higashide, Hinoda, Hinoda, Hinoda, Hostetter, Huang, Huitric, Hwang, Inazawa, Jean, John A. Thompson, Jones, Kamarck, Kasuga, Khan, Khan, Khan, Knapp, Kobata, Kodelja, Kolbinger, Kudo, Kupchik, Kuroki, Kuroki, Kuroki, Kuroki, Kuroki, Kuroki, Kuroki, Kurroki, Lai, Leon, Leslie, Leusch, Lewis, Lin, Lin, Lin, Lisanti, Losman, Mach, Margolis, Margolis, Martin, Matsuoka, McDonald, McLenachan, Monden, Mount, Nagata, Neumaier, Neumaier, Neumaier, Nichols, Niemann, Niemann, Niles, Novak-Hofer, Ocklind, Odin, Ogilvie, Oikawa, Oikawa, Oikawa, Oikawa, Oikawa, Paxton, Perkins, Perrotti, Pignatelli, Proudfoot, Ravetch, Ravetch, Rebstock, Rees-Jones, Rojas, Rooney, Rosen, Rosen, Rudert, Rudert, Ruoslahti, Sack, Salzer, Sato, Saunders, Schmid, Schonk, Schrewe, Schrewe, Schwarz, Schwarz, Sell, Sewell, Sharkey, Shively, Siepen, Slightom, Smale, Soeller, Staunton, Staunton, Streydio, Streydio, Streydio, Svenberg, Svenberg, Takami, Takeichi, Takeichi, Tatarinov, Tawaragi, Terry, Thomas, Thomas, Thompson, Thompson, Thompson, Thompson, Thompson, Tingström, Toribara, Toribara, Toth, Toth, Tran, Tsao, Tsujisaki, Tsujisaki, Tuan, Turbide, Van der Schoot, Van der Schoot, Von Kleist, Von Kleist, Von Kleist, Von Kleist, Vorličková, Wallner, Watanabe, Watanabe, Watt, Willcocks, Willcocks, Williams, Williams, Williams, Wolfgang Zimmermann, Yamaguchi, Yarden, Zheng, Zhou, Zimmermann, Zimmermann, Zimmermann, Zoubir, Öbrink   +236 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Recent Advances in the Chemical Biology of N-Glycans

Molecules, 2021
Asparagine-linked N-glycans on proteins have diverse structures, and their functions vary according to their structures. In recent years, it has become possible to obtain high quantities of N-glycans via isolation and chemical/enzymatic/chemoenzymatic ...
Asuka Shirakawa, Yoshiyuki Manabe, Koichi Fukase   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis [PDF]

, 2005
BACKGROUND AND AIMS: The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with ...
Arnott, Ian D, Drummond, Hazel, Fennell, Janice, Ho, Gwo-Tzer, Mowat, Craig, Nimmo, Elaine R, Satsangi, Jack, Tenesa, Albert   +7 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG

Microbial Cell Factories, 2012
Background Although the occurrence, biosynthesis and possible functions of glycoproteins are increasingly documented for pathogens, glycoproteins are not yet widely described in probiotic bacteria.
Lebeer Sarah, Claes Ingmar JJ, Balog Crina IA, Schoofs Geert, Verhoeven Tine LA, Nys Kris, von Ossowski Ingemar, de Vos Willem M, Tytgat Hanne LP, Agostinis Patrizia, Palva Airi, Van Damme Els JM, Deelder André M, De Keersmaecker Sigrid CJ, Wuhrer Manfred, Vanderleyden Jos   +15 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source