Results 61 to 70 of about 765,176 (310)

Antiviral mechanisms of two broad-spectrum monoclonal antibodies for rabies prophylaxis and therapy

Frontiers in Immunology, 2023
Rabies is an acute and lethal encephalomyelitis caused by lyssaviruses, among which rabies virus (RABV) is the most prevalent and important for public health.
Maira Zorzan, Martina Castellan, Matteo Gasparotto, Guilherme Dias de Melo, Barbara Zecchin, Stefania Leopardi, Alex Chen, Antonio Rosato, Antonio Rosato, Alessandro Angelini, Alessandro Angelini, Hervé Bourhy, Davide Corti, Laura Cendron, Paola De Benedictis   +14 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Additional file 8 of The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells

, 2023
Additional file 8. Supplemental Figure 8. Effects of Tamoxifen and Na-Orthovanadate on P-glycoprotein ATPase in AuxB1 and CHORC5 cells. ATPase activity of AuxB1 and CHORC5 was measure using purified plasma membranes expose to increasing concentrations of
Elias Georges (2367895), Rowa Bakadlag (15219437), Gabriel Georges (15200892), Georgia Limniatis (15219440)   +3 more
core   +1 more source

Fucosylation and protein glycosylation create functional receptors for cholera toxin

eLife, 2015
Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates ...
Amberlyn M Wands, Akiko Fujita, Janet E McCombs, Jakob Cervin, Benjamin Dedic, Andrea C Rodriguez, Nicole Nischan, Michelle R Bond, Marcel Mettlen, David C Trudgian, Andrew Lemoff, Marianne Quiding-Järbrink, Bengt Gustavsson, Catharina Steentoft, Henrik Clausen, Hamid Mirzaei, Susann Teneberg, Ulf Yrlid, Jennifer J Kohler   +18 more
doaj   +1 more source

Impact of mutations on the plant-based production of recombinant SARS-CoV-2 RBDs

Frontiers in Plant Science, 2023
Subunit vaccines based on recombinant viral antigens are valuable interventions to fight existing and evolving viruses and can be produced at large-scale in plant-based expression systems.
Valentina Ruocco, Ulrike Vavra, Julia König-Beihammer, Omayra C. Bolaños−Martínez, Somanath Kallolimath, Daniel Maresch, Clemens Grünwald-Gruber, Richard Strasser   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Blocking Variant Surface Glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation [PDF]

, 2009
Background: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream.
Gluenz Eva, Terry K Smith, Shulamit Michaeli, Susanne Kramer, Michaeli, Shulamit, Terry, Stephen, Terry K. Smith, Eva Gluenz, Smith, Terry K., Nadina Vasileva, Mark Carrington, Michaeli Shulamit, Vasileva, Nadina, Stephen Terry, Rudenko Gloria, Gull Keith, Gluenz, Eva, Keith Gull, Smith Terry K., Neil Portman, Portman, Neil, Smith, Terry K, Rudenko, Gloria, Terry Stephen, Vasileva Nadina, Gull, Keith, Carrington Mark, Carrington, Mark, Kramer, Susanne, Terry K. Smith, Portman Neil, Kramer Susanne, Gloria Rudenko, Smith, Terry K; id_orcid   +33 more
core   +2 more sources

N-ferrocenylmethyl-Derivatives As Spike Glycoprotein Inhibitors Of SARS-CoV-2 Using In Silico Approaches [PDF]

, 2020
Background and Objectives: By the end of 2019, a novel human coronavirus outbreak started in Wuhan and spread to the world becoming a global pandemic, patients were diagnosed with severe respiratory syndrome.
Touhami, Lanez, NADJIBA, ZEGHEB, LANEZ, Elhafnaoui   +2 more
core   +1 more source

Spatiotemporal Expression of Pregnancy-Specific Glycoprotein Gene rnCGMl in Rat Placenta [PDF]

, 1993
As a basis towards a better understanding of the role of the pregnancy-specific glycoprotein (PSG) family in the maintenance of pregnancy, detailed investigations are described on the expression of a recently identified rat PSG gene (rnCGM1) at the mRNA ...
Wolfgang Zimmermann, Zimmermann, Wolfgang, Sabine Rebstock, Weiss, Martina, Martina Weiss, Lucas, Kurt, Kurt Lucas, John Thompson, Rebstock, Sabine, Thompson, John A.   +9 more
core   +1 more source

Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Flavonoid Derivatives and Analogues

, 2016
Flavonoid derivatives were synthesized and tested for their ability to modulate P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) in vitro. These compounds belong to various flavonoid subclasses, namely:  chromones, azaisoflavones, and aurones ...
Jean Boutonnat (60167), Magali Barbier (60172), Xavier Ronot (60174), Ahcène Boumendjel (826902), Mohamed Hadjeri (2707498), Anne-Marie Mariotte (2655247)   +5 more
core   +1 more source