Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling. [PDF]
PLoS Computational Biology, 2013 Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions.
Sunhwan Jo +3 more
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Production and N-glycan engineering of Varlilumab in Nicotiana benthamiana [PDF]
Frontiers in Plant Science, 2023 N-glycan engineering has dramatically evolved for the development and quality control of recombinant antibodies. Fc region of IgG contains two N-glycans whose galactose terminals on Fc-glycan have been shown to increase the stability of CH2 domain and ...
Kim Dua Nguyen +9 more
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N-glycopedia: libraries for native N-glycan structural analysis [PDF]
Nature CommunicationsMeasurements of glycans modifying glycoproteins are hampered by the lack of standards that reflect the wide diversity in structure typically observed. To this end we exploit a large library of N-glycan standards comprised of a unique collection of 226 N ...
Christopher Ashwood, Richard D. Cummings
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Species-specific N-glycan patterns in animal and human breast milk samples [PDF]
Frontiers in NutritionThe main components of milk are protein, fat and carbohydrates. Glycans are complex carbohydrate structures covalently bound to proteins and lipids or exist freely in solutions.
Davide Ret +6 more
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Identification of a free-N-glycan with difucosylated type-1 lactosamine in cancerous tissue and its validation for cancer diagnosis by urinary testing [PDF]
Scientific ReportsNumerous urinary acidic free-glycan tumor marker candidates have been identified based on the glycan structure profiles of human cancer tissues. In this study, to identify novel glycan tumor markers, we performed precise glycan structural analysis ...
Miki Tanaka-Okamoto +8 more
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Bioengineering, 2023 Analytical methods fr direct quantitative N-glycan analysis require a sequence of sample preparation and clean-up steps that result in reduced glycan recovery. Therefore, we aimed to combine glycan release and labeling steps. Based on the hypothesis that
Mumtaz Kasim +8 more
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The Impact of Glycoengineering on the Endoplasmic Reticulum Quality Control System in Yeasts
Frontiers in Molecular Biosciences, 2022 Yeasts are widely used and established production hosts for biopharmaceuticals. Despite of tremendous advances on creating human-type N-glycosylation, N-glycosylated biopharmaceuticals manufactured with yeasts are missing on the market.
Mari A. Piirainen +2 more
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An Integrative Glycomic Approach for Quantitative Meat Species Profiling
Foods, 2022 It is estimated that food fraud, where meat from different species is deceitfully labelled or contaminated, has cost the global food industry around USD 6.2 to USD 40 billion annually.
Sean Chia +8 more
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The tobacco GNTI stem region harbors a strong motif for homomeric protein complex formation
Frontiers in Plant Science, 2023 IntroductionThe Golgi apparatus of plants is the central cellular organelle for glycan processing and polysaccharide biosynthesis. These essential processes are catalyzed by a large number of Golgi-resident glycosyltransferases and glycosidases whose ...
Jennifer Schoberer +8 more
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Engineering, 2023 The aim of this study was to explore the role of serum N-glycomic-derived models in diagnosing significant liver fibrosis and cirrhosis in 285 chronic hepatitis B (CHB) patients with normal (
Lin Wang +9 more
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