Results 21 to 30 of about 13,562,347 (304)

Glycan–protein interactions determine kinetics of N-glycan remodeling [PDF]

, 2021
A hallmark of N-linked glycosylation in the secretory compartments of eukaryotic cells is the sequential remodeling of an initially uniform oligosaccharide to a site-specific, heterogeneous ensemble of glycostructures on mature proteins.
Aebi, Markus; https://orcid.org/, Weiß, R Gregor; https://orcid.org/, Glockshuber, Rudi; https://orcid.org/, Giese, Christoph, Lin, Chia-Wei; https://orcid.org/, Mathew, Corina; https://orcid.org/, Losfeld, Marie-Estelle; https://orcid.org/, Riniker, Sereina; https://orcid.org/   +7 more
core   +1 more source

The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation

Scientific Reports, 2017
N-glycosylations can regulate the adhesive function of integrins. Great variations in both the number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin subunits.
Xiulei Cai, Aye Myat Myat Thinn, Zhengli Wang, Hu Shan, Jieqing Zhu   +4 more
doaj   +1 more source

Divergent Enzymatic Assembly of a Comprehensive 64‐Membered IgG N‐Glycan Library for Functional Glycomics

Advanced Science, 2023
N‐Glycosylation, a main post‐translational modification of Immunoglobulin G (IgG), plays a significant role in modulating the immune functions of IgG. However, the precise function elucidation of IgG N‐glycosylation remains impeded due to the obstacles ...
Wenjing Ma, Zhuojia Xu, Yuhan Jiang, Jialin Liu, Dandan Xu, Wei Huang, Tiehai Li   +6 more
doaj   +1 more source

Clinical implications of serum N‐glycan profiling as a diagnostic and prognostic biomarker in germ‐cell tumors

Cancer Medicine, 2017
Serum biomarker monitoring is essential for management of germ‐cell tumors (GCT). However, not all GCT are positive for conventional tumor markers. We examined whether serum N‐glycan‐based biomarkers can be applied for detection and prognosis in patients
Takuma Narita, Shingo Hatakeyama, Tohru Yoneyama, Shintaro Narita, Shinichi Yamashita, Koji Mitsuzuka, Toshihiko Sakurai, Sadafumi Kawamura, Tatsuo Tochigi, Ippei Takahashi, Shigeyuki Nakaji, Yuki Tobisawa, Hayato Yamamoto, Takuya Koie, Norihiko Tsuchiya, Tomonori Habuchi, Yoichi Arai, Chikara Ohyama   +17 more
doaj   +1 more source

Effect of vitamin D supplementation on N‐glycan branching and cellular immunophenotypes in MS

Annals of Clinical and Translational Neurology, 2020
Objective To investigate the effect of cholecalciferol (vitamin D3) supplementation on peripheral immune cell frequency and N‐glycan branching in patients with relapsing‐remitting multiple sclerosis (RRMS).
Priscilla Bäcker‐Koduah, Carmen Infante‐Duarte, Federico Ivaldi, Antonio Uccelli, Judith Bellmann‐Strobl, Klaus‐Dieter Wernecke, Michael Sy, Michael Demetriou, Jan Dörr, Friedemann Paul, Alexander Ulrich Brandt   +10 more
doaj   +1 more source

Pn-AqpC-Mediated Fermentation Pattern Coordination with the Two-Component System 07 Regulates Host N-Glycan Degradation of Streptococcus pneumoniae

Microbiology Spectrum, 2022
The opportunistic pathogen Streptococcus pneumoniae (pneumococcus) is a human nasopharyngeal commensal, and host N-glycan metabolism promotes its colonization and invasion.
Kaiqiang Shen, Qingqing Hu, Lin Zhu, Wenshuang Miu, Yuzhu Dong, Fu Ren, Xiuzhu Dong, Huichun Tong   +7 more
doaj   +1 more source

Glycan-specific RF model training performances.

, 2021
Training performance of glycan-specific RF models measured with nested 5x cross-validation. Recall (left y-axis) and precision (right y-axis) of glycan-specific random forest models is shown by the split violin plots, with the left-hand distributions ...
Chris Bailey-Kellogg (682345), Daniel E. Mattox (10043639)   +1 more
core   +1 more source

Transient Production of Human β-Glucocerebrosidase With Mannosidic-Type N-Glycan Structure in Glycoengineered Nicotiana benthamiana Plants

Frontiers in Plant Science, 2021
Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose
Naphatsamon Uthailak, Hiroyuki Kajiura, Hiroyuki Kajiura, Ryo Misaki, Ryo Misaki, Kazuhito Fujiyama, Kazuhito Fujiyama, Kazuhito Fujiyama   +7 more
doaj   +1 more source

Host glycocalyx captures HIV proximal to the cell surface via oligomannose-GlcNAc glycan-glycan interactions to support viral entry

, 2022
Here, we present ultrastructural analyses showing that incoming HIV are captured near the lymphocyte surface in a virion-glycan-dependent manner. Biophysical analyses show that removal of either virion- or cell-associated N-glycans impairs virus-cell ...
Aggarwal, Anupriya, Purcell, Damian FJ, Turville, Stuart G, Haselhorst, Thomas, Stow, Jennifer L, Spillings, Belinda L, Garcia-Minambres, Albert, Jennings, Michael P, Mak, Johnson, Day, Christopher J, Condon, Nicholas D   +10 more
core   +1 more source

Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody

Nature Communications, 2023
Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and determines its specificity for Fcγ receptors ...
Aaron Gupta, Kevin S. Kao, Rachel Yamin, Deena A. Oren, Yehuda Goldgur, Jonathan Du, Pete Lollar, Eric J. Sundberg, Jeffrey V. Ravetch   +8 more
doaj   +1 more source