Results 51 to 60 of about 765,176 (310)

Glycoprotein reglucosylation

Methods, 2005
Proteins following the secretory pathway acquire their proper tertiary and in certain cases also quaternary structures in the endoplasmic reticulum (ER). Incompletely folded species are retained in the ER and eventually degraded. One of the molecular mechanisms by which cells achieve this conformational sorting is based on monoglucosylated N-glycans ...
Trombetta, E. Sergio, Parodi, Armando José A.   +1 more
openaire   +3 more sources

Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans [PDF]

, 2009
Background: The Y-box binding protein 1 (YB-1) is considered to be one of the key regulators of transcription and translation. However, so far only limited knowledge exists regarding its cellular distribution in the adult brain.Results: Analysis of YB-1 ...
Maria S Balda, Pekcec, A, Baumgaertner, Wolfgang, Balda Maria S, Pekcec, Anton, Wehmeyer, A, Baumgärtner Wolfgang, Potschka Heidrun, Baumgartner, W, Christina Fuest, Potschka, H, Unkruer, B, Wehmeyer Andrea, Fuest, C, Horn Anja, Anja Horn, Balda, MS, Heidrun Potschka, Anton Pekcec, Horn, Anja, Horn, A, Wolfgang Baumgärtner, Balda, Maria S., Unkrueer, Bernadette, Unkrüer Bernadette, Bernadette Unkrüer, Andrea Wehmeyer, Wehmeyer, Andrea, Fuest, Christina, Pekcec Anton, Potschka, Heidrun, Fuest Christina   +31 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects

Journal of Lipid Research, 2008
Lipid transfer inhibitor protein (LTIP) is an important regulator of cholesteryl ester transfer protein function. We report the development of an immunoassay for LTIP and its use to quantify LTIP in plasma of varying lipid contents.
Richard E. Morton, Hannah M. Gnizak, Diane J. Greene, Kyung-Hyun Cho, Victor M. Paromov   +4 more
doaj   +1 more source

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker

eLife, 2022
Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the ultralong protein von Willebrand factor (VWF) to GPIbα on platelets to form a platelet plug.
Klaus Bonazza, Roxana E Iacob, Nathan E Hudson, Jing Li, Chafen Lu, John R Engen, Timothy A Springer   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An oligosaccharyltransferase from Leishmania donovani increases the N-glycan occupancy on plant-produced IgG1

Frontiers in Plant Science, 2023
N-Glycosylation of immunoglobulin G1 (IgG1) at the heavy chain Fc domain (Asn297) plays an important role for antibody structure and effector functions.
Gernot Beihammer, Gernot Beihammer, Julia König-Beihammer, Benjamin Kogelmann, Benjamin Kogelmann, Valentina Ruocco, Clemens Grünwald-Gruber, Marc-André D’Aoust, Pierre-Olivier Lavoie, Pooja Saxena, Johannes S. Gach, Herta Steinkellner, Richard Strasser   +12 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Glycoprotein hormone receptors in GtoPdb v.2023.1 [PDF]

, 2023
Glycoprotein hormone receptors (provisional nomenclature [47]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers ...
Pawson, Adam J, Marvin Gershengorn, Adam J Pawson, James A. Dias, Costagliola, Sabine, Dias, James A., Segaloff, Deborah L., Sabine Costagliola, Axel P.N. Themmen, Gershengorn, Marvin, Themmen, Axel P.N., Deborah L. Segaloff, Vassart, Gilbert, Gilbert Vassart   +13 more
core   +1 more source

Bioactive sialylated-mucin (SiaMuc) glycopeptide produced from enzymatic hydrolysis of edible swiftlet’s nest (ESN): degree of hydrolysis, nutritional bioavailability, and physicochemical characteristics

International Journal of Food Properties, 2022
The swiftlet’s nest is an edible bird’s nest (EBN) produced from dried gelatinized saliva secreted by swiftlets during the breeding season. It is widely used in industries for its high nutritional values and health benefits.
Tan Hui Yan, Sue Lian Mun, Jia Lin Lee, Seng Joe Lim, Nur Aliah Daud, Abdul Salam Babji, Shahrul Razid Sarbini   +6 more
doaj   +1 more source