Results 151 to 160 of about 964,671 (415)
Biofilm Control by Active Topography with Mucin Coating
Advanced Functional Materials, EarlyView.This study reports a new antifouling strategy based on a bioinspired design. Mucin coating enhances biofilm control by active topography with beating micron‐sized pillars. Besides the mechanical force of beating pillars, the antibiofilm activities also involve biological factors since mucin coating inhibits swarming motility and c‐di‐GMP synthesis in ...
Zehui Han +4 more
wiley +1 more source
P-glycoprotein Inhibition for Optimal Drug Delivery
Drug Target Insights, 2013 P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents
Md. Lutful Amin
semanticscholar +1 more source
Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission [PDF]
, 2010 Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission. In this study we use a novel infectious coculture system to examine these alternative modes of infection.
Balfe, Peter +12 more
core +4 more sources
Advanced Functional Materials, EarlyView.The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang +9 more
wiley +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]
, 1992 Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F +3 more
core +1 more source
Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
Journal of Clinical Investigation, 1995 We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a profound effect on the tissue distribution and elimination of vinblastine and ivermectin, and hence on the toxicity of these ...
A. Schinkel +4 more
semanticscholar +1 more source
Evaluation of QSAR and ligand enzyme docking for the identification of ABCB1 substrates [PDF]
, 2013 P-glycoprotein (P-gp) is an efflux pump that belongs to ATP-binding cassette (ABC) transporter family embedded in the membrane bilayer. P-gp is a polyspecific protein that has demonstrated its function as a transporter of hydrophobic drugs as well as ...
Ghafourian, T. +3 more
core