Results 281 to 290 of about 1,005,229 (334)

Potential Drug Interactions in Psychiatric Patients Undergoing Pangenotypic Therapy for Hepatitis C Virus Infection. [PDF]

Pharmaceuticals (Basel)
Dybowska D, Pawłowska M, Kozielewicz D.
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Arrival of Oropouche Virus in a Nonendemic Area in Northeastern Brazil, 2024. [PDF]

J Med Virol
Nascimento JPM, Araújo TPG, Araújo MA, Arruda MMG, Simplicio VP, Calheiros EB, Pereira E Silva AC, Silva LMN, Santos MR, Lima MC, Santos HO, Bassi ÊJ, Borges AA, Leite AB, Silva-Júnior A.   +14 more
europepmc   +1 more source

Small glycomimetic antagonists of the cytomegalovirus glycoprotein UL141 prevent binding to TRAIL death receptor

Ivana Nemčovičová, Juraj Kóňa, Monika Poláková, Tomáš Klunda, Andrej Bitala, Mário Benko, Simona Lenhartová, Marek Nemčovič   +7 more
openalex   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Pharmacological Evaluation of Ticagrelor and Aspirin Versus Clopidogrel and Aspirin Pretreatment on Infarct Artery Flow in Patients with Acute STEMI. [PDF]

Pharmaceuticals (Basel)
Opancina M, Opancina V, Milosavljević MN, Pejčić AV, Stepovic M, Jovic Z.   +5 more
europepmc   +1 more source

Author response: SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

Daisuke Mashiko, Shingo Tonai, Haruhiko Miyata, Martin M. Matzuk, Masahito Ikawa   +4 more
openalex   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

Re-sensitization of cancer multidrug resistance through P-gp, MRP1 and BCRP modulation: advances in terpenoids based cancer therapy. [PDF]

Discov Oncol
Pandey P, Singh A, Lakhanpal S, Rekha M, Mangaraj S, Verma M, Upadhye VJ, Khan F.   +7 more
europepmc   +1 more source