Results 281 to 290 of about 1,203,966 (394)

Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity. [PDF]

open access: yesProc Natl Acad Sci U S A
Bentley K   +14 more
europepmc   +1 more source

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

open access: yesAdvanced Therapeutics, EarlyView.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn   +7 more
wiley   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

open access: yesAdvanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack   +13 more
wiley   +1 more source

A Mutation-Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi-Strains: A Study Using Glycoprotein of LASV. [PDF]

open access: yesJ Cell Mol Med
Mishra SK   +7 more
europepmc   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

open access: yesAdvanced Theory and Simulations, EarlyView.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer   +7 more
wiley   +1 more source

Halobacterial glycoprotein biosynthesis [PDF]

open access: yesBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1987
openaire   +4 more sources

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