Results 321 to 330 of about 698,632 (367)

Structures of two lyssavirus glycoproteins trapped in pre- and post-fusion states and the implications on the spatial-temporal conformational transition along with pH-decrease. [PDF]

PLoS Pathog
Yang F, Lin S, Yuan X, Shu S, Yu Y, Yang J, Ye F, Chen Z, He B, Li J, Zhao Q, Ye H, Cao Y, Lu G.   +13 more
europepmc   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

[Retracted] Feroniellin A‑induced autophagy causes apoptosis in multidrug‑resistant human A549 lung cancer cells. [PDF]

Int J Oncol
Kaewpiboon C, Surapinit S, Malilas W, Moon E, Phuwapraisirisan P, Tip-Pyang S, Johnston RN, Koh SS, Assavalapsakul W, Chung YH.   +9 more
europepmc   +1 more source

The tacrolimus concentration‐to‐dose ratio is associated with kidney function in heart transplant recipients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen, Teun B. Petersen, Boris C. A. Seijkens, Jasper J. Brugts, Kadir Caliskan, Alina A. Constantinescu, Brenda C. M. de Winter, Isabella Kardys, Dennis A. Hesselink, Olivier Manintveld   +9 more
wiley   +1 more source

Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation. [PDF]

Cardiovasc Diabetol
Llop D, Rehues P, Paredes S, Guardiola M, Girona J, Rosales R, Esteban Y, Masana L, Ibarretxe D, Vallvé JC, Ribalta J.   +10 more
europepmc   +1 more source

The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties

BioEssays, EarlyView.
Mucus viscosity changes as spermatozoa travel through the female reproductive tract to the egg in humans, bovines, mice, and other mammals. These changes may aid in spermatozoa navigation. However, limited information is available on the viscoelastic properties of female reproductive tract mucus, and consistent measurement techniques are lacking ...
Luke Achinger, Derek F. Kluczynski, Abigail Gladwell, Holly Heck, Faith Zhang, Ethan Good, Alexis Waggoner, Mykala Reinhart, Megan Good, Dawson Moore, Dennis Filatoff, Supriya Dhar, Elisa Nigro, Lucas Flanagan, Sunny Yadav, Trinity Williams, Aniruddha Ray, Tariq A. Shah, Matthew W. Liberatore, Tomer Avidor‐Reiss   +19 more
wiley   +1 more source

The nomogram model predicts relapse risk in myelin oligodendrocyte glycoprotein antibody-associated disease: a single-center study. [PDF]

Front Immunol
Cheng J, Wang Z, Wang J, Pang X, Wang J, Zhang M, Guo J, Meng H.   +7 more
europepmc   +1 more source

Changes of leucine-rich alpha 2 glycoprotein could be a marker of changes of endoscopic and histologic activity of ulcerative colitis. [PDF]

Sci Rep
Aoyama Y, Hiraoka S, Yasutomi E, Inokuchi T, Tanaka T, Takei K, Igawa S, Takeuchi K, Takahara M, Toyosawa J, Yamasaki Y, Kinugasa H, Kato J, Okada H, Otsuka M.   +14 more
europepmc   +1 more source

Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody-Associated Disease. [PDF]

Brain Behav
San Martin DL, Portela Filho MB, Rocchi C, Hamid S, Huda S.   +4 more
europepmc   +1 more source