Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji +9 more
wiley +1 more source
Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner. [PDF]
Kaizuka Y, Machida R.
europepmc +1 more source
Navigating the blood-brain barrier to blood-brain tumor barrier transition: microvascular P-glycoprotein and CD146 potentially contribute to glioma grading. [PDF]
Mora A +10 more
europepmc +1 more source
Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence [PDF]
Buchmeier, M J +3 more
core
Comparative analysis of 3 qPCR primer-probe sets for the detection of equid alphaherpesvirus 1. [PDF]
Kambayashi Y +5 more
europepmc +1 more source
Immunogenicity of differentially glycosylated Marburg virus glycoproteins expressed in mammalian and insect cells. [PDF]
Li J +15 more
europepmc +1 more source
Discovery and characterization of Sager Creek virus, a new orthohantavirus in prairie voles (Microtus ochrogaster). [PDF]
Mull N +6 more
europepmc +1 more source
Retraction of "Aptamer-Gold(III) Complex Nanoparticles: A New Way to Detect Cu, Zn SOD Glycoprotein". [PDF]
Dekhili R +5 more
europepmc +1 more source

