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Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

open access: yesAdvanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji   +9 more
wiley   +1 more source

Navigating the blood-brain barrier to blood-brain tumor barrier transition: microvascular P-glycoprotein and CD146 potentially contribute to glioma grading. [PDF]

open access: yesFluids Barriers CNS
Mora A   +10 more
europepmc   +1 more source

Comparative analysis of 3 qPCR primer-probe sets for the detection of equid alphaherpesvirus 1. [PDF]

open access: yesJ Vet Diagn Invest
Kambayashi Y   +5 more
europepmc   +1 more source

Immunogenicity of differentially glycosylated Marburg virus glycoproteins expressed in mammalian and insect cells. [PDF]

open access: yesVirol J
Li J   +15 more
europepmc   +1 more source

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