Results 321 to 330 of about 604,492 (391)

Self-assembled PROTACs enable glycoproteins degradation in the living cells. [PDF]

Chem Sci
Chen H, Zang L, Kielkowski P.
europepmc   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Uncommon N-Glycan Structures in Anhydrobiotic Tardigrades. [PDF]

Mol Cell Proteomics
Yagi H, Saito T, Guu SY, Yamakawa N, Shimamura S, Kondo S, Yagi-Utsumi M, Takai K, Furukawa JI, Guérardel Y, Khoo KH, Arakawa K, Kato K.   +12 more
europepmc   +1 more source

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

Advanced Science, EarlyView.
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou, Yuqing Lv, Lin Li, Shukui Zhang, Jiaqi Liang, Chengchao Wu, Enyu Huang, Jianwei Jiao, Jingjing Zhang   +8 more
wiley   +1 more source

Achieving cell-type selectivity in metabolic oligosaccharide engineering. [PDF]

RSC Chem Biol
Helmeke MMB, Haynie-Cion RL, Pratt MR.
europepmc   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Glycomics and Glycoproteomics Reveal Distinct Oligomannose Carriers Across Bladder Cancer Stages. [PDF]

Int J Mol Sci
Relvas-Santos M, Ferreira D, Brandão A, Afonso LP, Santos LL, Silva AMN, Ferreira JA.   +6 more
europepmc   +1 more source

Altered glycosylation of EVs in cancers: galectin-3-binding protein (LGALS3BP). [PDF]

Discov Oncol
Koh Kok JY, Goh BH, Lee WL.
europepmc   +1 more source

Fast NMR-Based Assessment of Cancer-Associated Protein Glycosylations from Serum Samples. [PDF]

Anal Chem
Rudolph L, Krellmann R, Castven D, Jegodzinski L, Deriš H, Štambuk J, Mölbitz J, Dechent L, Sperling K, Lindloge M, Friedrich N, Schmelter F, Föh B, Trbojević-Akmačić I, Sina C, Nauck M, Petersmann A, Marquardt JU, Günther UL, Mallagaray A.   +19 more
europepmc   +1 more source