Results 21 to 30 of about 33,448 (258)
Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE
Nature Communications, 2022 EndoE is a multi-domain glycoside hydrolase of the human pathogen Enterococcus faecalis. Here, the authors present crystal structures of EndoE and provide biochemical insights into the molecular basis of EndoE’s substrate specificity and catalytic ...
Mikel García-Alija +12 more
doaj +1 more source
Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. [PDF]
, 2014 BackgroundBacteroides spp. form a significant part of our gut microbiome and are well known for optimized metabolism of diverse polysaccharides. Initial analysis of the archetypal Bacteroides thetaiotaomicron genome identified 172 glycosyl hydrolases and
Axelrod, Herbert L +7 more
core +2 more sources
Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of glycoside hydrolase. [PDF]
, 2014 BackgroundGut microbiome metagenomics has revealed many protein families and domains found largely or exclusively in that environment. Proteins containing the GxGYxYP domain are over-represented in the gut microbiota, and are found in Polysaccharide ...
Chang, Yuanyuan +5 more
core +2 more sources
Biomass-degrading glycoside hydrolases of archaeal origin [PDF]
Biotechnology for Biofuels, 2020 AbstractDuring the last decades, the impact of hyperthermophiles and their enzymes has been intensively investigated for implementation in various high-temperature biotechnological processes. Biocatalysts of hyperthermophiles have proven to show extremely high thermo-activities and thermo-stabilities and are identified as suitable candidates for ...
Suleiman, Marcel +2 more
openaire +3 more sources
Bioprospecting for bacteria producing glycoside hydrolases with potential biotechnological applications [PDF]
Anais da Academia Brasileira de CiênciasGlycoside hydrolases are a diverse group of enzymes that act on various α-glucans, exhibiting distinct product specificities. Bioprospecting for bacteria capable of producing novel glycoside hydrolases represents a significant area of interest in ...
JULIETA DE LAS MERCEDES CASTILLO +2 more
doaj +1 more source
Communications Biology, 2023 Most Gram-negative bacteria synthesize osmo-regulated periplasmic glucans (OPG) in the periplasm or extracellular space. Pathogenicity of many pathogens is lost by knocking out opgG, an OPG-related gene indispensable for OPG synthesis.
Sei Motouchi +3 more
doaj +1 more source
Frontiers in Microbiology, 2016 Tailed phages with genomes of larger than 200 kbp are classified as Jumbo phages and exhibited extremely high uncharted diversity. The genomic annotation of Jumbo phage is often disappointing because most of the predicted proteins, including structural ...
Yihui eYuan, Meiying eGao
doaj +1 more source
Biotechnology for Biofuels and Bioproducts, 2023 Background The combination of cellulase and lytic polysaccharide monooxygenase (LPMO) is known to boost enzymatic saccharification of cellulose. Although the synergy between cellulases (GH5, 6 or 7) and LPMOs (AA9) has been extensively studied, the ...
Xing Qin +9 more
doaj +1 more source
Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases
JACS Au, 2023 Allylic cyclitols were investigated as covalent inhibitors of glycoside hydrolases by chemical, enzymatic, proteomic, and computational methods. This approach was inspired by the C7 cyclitol natural product streptol glucoside, which features a potential carbohydrate leaving group in the 4-position (carbohydrate numbering).
Grayfer, Tatyana D +11 more
openaire +2 more sources
Biotechnology for Biofuels, 2018 Background Metabolism of carbon bound in wheat arabinoxylan (WAX) polysaccharides by bacteria requires a number of glycoside hydrolases active toward different bonds between sugars and other molecules.
Brady D. Lee +3 more
doaj +1 more source