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The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane. [PDF]

open access: yesJ Biol Chem
Nagar R   +9 more
europepmc   +1 more source
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Structure of human glycosylphosphatidylinositol transamidase

Nature Structural & Molecular Biology, 2022
Glycosylphosphatidylinositol (GPI) molecules are complex glycophospholipids and serve as membrane anchors for tethering many proteins to the cell surface. Attaching GPI to the protein in the endoplasmic reticulum (ER) is catalyzed by the transmembrane GPI transamidase (GPIT) complex, which is essential for maturation of the GPI-anchored proteins.
Hongwei Zhang   +9 more
openaire   +2 more sources

Glycosylphosphatidylinositols

Laboratory Techniques in Biochemistry and Molecular Biology / Edited By T S Work [and] E Work, 2003
exaly   +2 more sources

Chemical Biology of Glycosylphosphatidylinositol Anchors

Angewandte Chemie International Edition, 2012
AbstractGlycosylphosphatidylinositols (GPIs) are complex glycolipids that are covalently linked to the C‐terminus of proteins as a posttranslational modification. They anchor the attached protein to the cell membrane and are essential for normal functioning of eukaryotic cells. GPI‐anchored proteins are structurally and functionally diverse.
Tsai, Y., Liu, X., Seeberger, P.
openaire   +3 more sources

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