Sensitive Method To Analyze Cell Surface GPI-Anchored Proteins Using DNA Hybridization Chain Reaction-Mediated Signal Amplification. [PDF]
Kundu S +5 more
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The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane. [PDF]
Nagar R +9 more
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Inherited glycosylphosphatidylinositol deficiency: a review from molecular and clinical perspectives. [PDF]
Li S, Tang Q, Jiang Y, Chen X.
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Target Protein Expression on Tetrahymena thermophila Cell Surface Using the Signal Peptide and GPI Anchor Sequences of the Immobilization Antigen of Cryptocaryon irritans. [PDF]
Watanabe Y +4 more
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Drosophila models of phosphatidylinositol glycan biosynthesis class A congenital disorder of glycosylation (PIGA-CDG) mirror patient phenotypes. [PDF]
Thorpe HJ +5 more
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Structure of human glycosylphosphatidylinositol transamidase
Nature Structural & Molecular Biology, 2022Glycosylphosphatidylinositol (GPI) molecules are complex glycophospholipids and serve as membrane anchors for tethering many proteins to the cell surface. Attaching GPI to the protein in the endoplasmic reticulum (ER) is catalyzed by the transmembrane GPI transamidase (GPIT) complex, which is essential for maturation of the GPI-anchored proteins.
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Chemical Biology of Glycosylphosphatidylinositol Anchors
Angewandte Chemie International Edition, 2012AbstractGlycosylphosphatidylinositols (GPIs) are complex glycolipids that are covalently linked to the C‐terminus of proteins as a posttranslational modification. They anchor the attached protein to the cell membrane and are essential for normal functioning of eukaryotic cells. GPI‐anchored proteins are structurally and functionally diverse.
Tsai, Y., Liu, X., Seeberger, P.
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