Results 81 to 90 of about 10,284 (253)

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source

Bacillus cereus Enhanced Medicinal Ingredient Biosynthesis in Glycyrrhiza uralensis Fisch. Under Different Conditions Based on the Transcriptome and Polymerase Chain Reaction Analysis [PDF]

, 2022
Yu Zhang, Duoyong Lang, Wenjin Zhang, Xinhui Zhang   +3 more
openalex   +1 more source

A Novel Biflavonoid from Roots of Glycyrrhiza uralensis Cultivated in China

Chemical and Pharmaceutical Bulletin, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Hong, Bai, Wei, Li, Kazuo, Koike, Deqiang, Dou, Yuping, Pei, Yingjie, Chen, Tamotsu, Nikaido   +6 more
openaire   +3 more sources

Medicine‐Food Plant Polysaccharides Modulate Diabetes and Diabetic Complications Through Maintaining Gut Function: A Review

Food Frontiers, Volume 6, Issue 6, Page 2720-2765, November 2025.
Polysaccharides derived from medicine‐food plants restore intestinal barrier integrity and microbiota balance while modulating short‐chain fatty acid levels. These modifications significantly alleviate diabetes and its complications, including nephropathy, retinopathy, cardiovascular disease, and neuropathy.
Yi Long, Wanglong Yu, Pingping Yang, Minxuan Xu, Jitao Ling, Yuting Wu, Xiao Liu, Liu Ouyang, Yan Xiong, Jianping Liu, Yiming Gan, Jing Zhang, Peng Yu, Deju Zhang   +13 more
wiley   +1 more source

Department of Kampo-pharmaceutics [PDF]

, 2006
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
何 菊秀, 兜山 貴子, 谿 忠人
core   +1 more source

Spatio-Temporal Selection of Reference Genes in the Two Congeneric Species of \u3ci\u3eGlycyrrhiza\u3c/i\u3e [PDF]

, 2021
Glycyrrhiza, a genus of perennial medicinal herbs, has been traditionally used to treat human diseases, including respiratory disorders. Functional analysis of genes involved in the synthesis, accumulation, and degradation of bioactive compounds in these
An, Yu, Li, Ming, Li, Yongqing, Li, Yuping, Liang, Xiaoju, Wang, Ying, Yuan, Ling, Zhou, Xuguo   +7 more
core   +1 more source

Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress

Brain and Behavior, Volume 15, Issue 10, October 2025.
Ononin alleviates postoperative cognitive dysfunction in aged mice by regulating neuroinflammation and oxidative stress. ABSTRACT Objective Postoperative cognitive dysfunction (POCD) is a serious neurological complication that currently lacks effective clinical prevention and treatment.
Ming Li, Qingmei Peng, Min Zhu, Qilin Liu, Simin Yang, Cansheng Gong, Jingyan Lin, Qingbo Yu   +7 more
wiley   +1 more source

Advantages and Possibility of Transcription Factors FOXOs in HCC

Cell Biochemistry and Function, Volume 43, Issue 10, October 2025.
ABSTRACT The forkhead frame O protein (forkhead box class O proteins, FOXOs) is a highly conserved family of transcription factors, consisting of four members: FOXO 1, FOXO 3, FOXO 4, and FOXO 6. The FOXOs protein family is a ubiquitously expressed transcription factor involved in the regulation of cell cycle, cell proliferation, apoptosis, autophagy ...
Gu Xiufeng, Hu Zhiping, Wang Jingzhi
wiley   +1 more source

Suitable habitat prediction and desertified landscape remediation potential of three medicinal Glycyrrhiza species in China

Scientific Reports
Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata are significant medicinal plants in traditional Chinese medicine. They also contribute to ecological protection and restoration in the arid and semi-arid regions of Northwest China.
Fanyan Ma, Xiang Huang, Zhenan Yang, Panxin Niu, Keyao Pang, Mei Wang, Guangming Chu   +6 more
doaj   +1 more source

Metabolomics reveals the differential regulatory mechanisms of quality and flavonoid biosynthetic pathways during the drying process of varieties licorice

Food Chemistry: X
Flavonoids are one of the major chemical components in licorice. However, during the drying process, their chemical stability, content, and biological activity can all change.
Lichun Zhu, Mengqin Li, Xuetao Zhang, Qian Zhang, Xuhai Yang, Zhihua Geng   +5 more
doaj   +1 more source