Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
L-plastin Interacts with Receptor for Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Transduces Antiapoptotic Signaling in Human Eosinophils [PDF]
, 2007 Travis W. Young +4 more
openalex +1 more source
Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +9 more
wiley +1 more source
M@GM@De ce qui est fait, rien n’est beau et rien n’est bon si ce n’est pas utile aux autres. Le sujet doit commencer par ce don en constance désespérante comme le don hiératique mis en axiome probant et principal par toutes les religions depuis des ...
Bernard Troude
doaj +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Effect of mulching materials on the soil temperature, soil water potential, number and weight tubers of organic potatoes [PDF]
, 2011 The mulching with chopped grass (GM) and black textile mulch (BTM) were compared to non-mulching control variant (C) with mechanical cultivation in two regions of the Czech Republic.
core
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
AGRICULTURAL BIOTECHNOLOGY AND ORGANIC AGRICULTURE: NATIONAL ORGANIC STANDARDS, LABELING AND SECOND-GENERATION OF GM PRODUCTS [PDF]
This paper examines the effect of the introduction of labels for products of biotechnology on the markets for GM, conventional, and organic food products.
Giannakas, Konstantinos +1 more
core +1 more source
Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial. [PDF]
, 2019 Background The effects of race on response to medical therapy in people with peripheral artery disease ( PAD ) are unknown. Methods and Results In the PROPEL (Progenitor Cell Release Plus Exercise to Improve Functional Performance in PAD) Trial, PAD ...
Criqui, Michael H +11 more
core +1 more source