Results 121 to 130 of about 680,582 (292)

GM-0111 inhibits osteoclast formation independent of RANKL-RANK interaction.

open access: yes, 2016
GM-0111 binds to RANKL with high affinity (KD = 3.29 nM) (A), but does not inhibit the interaction between RANKL and its receptor RANK (B) (n = 3). RANKL induces NF-κB-mediated cell signaling in a dose-dependent manner (C), but GM-0111 does not reduce ...
Narayanam V. Rao (356295)   +6 more
core   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad   +22 more
wiley   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno   +19 more
wiley   +1 more source

The Impact of Labeling Practices on Perceived Quality of GM Food Products: A Revealed Preferences Approach [PDF]

open access: yes
This article contributes to the ongoing discussion about the impact of different labeling practices on the quality of genetically modified (GM) food products as perceived by the consumer. Thus far, many studies have adopted a stated preferences approach,
Hobbs, Jill E.   +2 more
core  

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

GM-1111 reduces blood and tissue biomarkers associated with allergy and Th2-mediated adaptive immunity.

open access: yes, 2018
Compared to controls, animals treated with A. fumigatus exhibited significant increases in (A) CD4+ T cells found in the sinonasal tissues (pA. fumigatus + PBS; n = 12, A. fumigatus + GM-1111), expressed as an infiltration severity index based on numbers
Jeremiah A. Alt (4389271)   +6 more
core   +1 more source

Validation of a Duplex Digital PCR Assay for the Quantification of the NK603 Maize Event Across Three dPCR Platforms

open access: yesFoods
In the European Union, mandatory labeling of food and feed products is required when authorized genetically modified organisms (GMOs) exceed 0.9% per ingredient, necessitating reliable analytical methods for official control laboratories.
Daniela Verginelli   +8 more
doaj   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab   +19 more
wiley   +1 more source

Homologaciones automaticas GM colmotores

open access: yes, 2022
El presente informe describe y explica las funciones y actividades que se desarrollaron en el área de regulaciones de la empresa GM Colmotores como pasantía, dicha organización se especializa en la fabricación y distribución de buses y camiones en el ...
Diaz Rodríguez, William
core  

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