Results 191 to 200 of about 51,102 (238)

Distributed NE and GNE seeking for heterogeneous multi-player games over directed communication networks.

Chaos
The non-cooperation game with heterogeneous dynamics is of both theoretical significance and practical relevance because of its extensive penetration into various fields, such as the game confrontation composed of unmanned aerial vehicles and unmanned ...
Qianle Tao, Yongfang Liu, Chengxin Xian, Yu Zhao, Guanghui Wen   +4 more
semanticscholar   +1 more source

Potential small effector molecules restoring cellular defects due to sialic acid biosynthetic enzyme deficiency: Pathological relevance to GNE myopathy.

Biochemical Pharmacology
GNEM (GNE Myopathy) is a rare neuromuscular disease caused due to biallelic mutations in sialic acid biosynthetic GNE enzyme (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine Kinase).
Fluencephila Mashangva, Jyoti Oswalia, Shagun Singh, Ranjana Arya   +3 more
semanticscholar   +1 more source

Pseudoexon activation by deep intronic variation in GNE myopathy with thrombocytopenia

Muscle and Nerve
GNE myopathy is a rare autosomal recessive disorder caused by pathogenic variants in the GNE gene, which is essential for the sialic acid biosynthesis pathway.
Kexin Jiao, Nachuan Cheng, X. Huan, Jialong Zhang, Yu Ding, Xinghua Luan, Lingchun Liu, Xilu Wang, Bochen Zhu, Kunzhao Du, Jiale Fan, Mingshi Gao, Xingyu Xia, Ningning Wang, Tao Wang, J. Xi, S. Luo, Jiahong Lu, Chongbo Zhao, D. Yue, Wenhua Zhu   +20 more
semanticscholar   +1 more source

Novel variants and genotype-phenotype correlation in a multicentre cohort of GNE myopathy in China

Journal of Medical Genetics
Background GlcNAc2-epimerase (GNE) myopathy is a rare autosomal recessive disorder caused by pathogenic variants in the GNE gene, which is essential for the sialic acid biosynthesis pathway.
Kexin Jiao, Jialong Zhang, Qiuxiang Li, Xiaoqing Lv, Yanyan Yu, Bochen Zhu, Huahua Zhong, Xu-en Yu, Jia Song, Q. Ke, F. Qian, Xinghua Luan, Xiaojie Zhang, Xueli Chang, Liang Wang, Meirong Liu, Jihong Dong, Zhangyu Zou, Bitao Bu, Haishan Jiang, Lingchun Liu, Yue Li, D. Yue, Xuechun Chang, Yongsheng Zheng, Ningning Wang, Mingshi Gao, Xingyu Xia, Nachuan Cheng, Tao Wang, S. Luo, J. Xi, Jie Lin, Jiahong Lu, Chongbo Zhao, Huan Yang, P. Lin, Daojun Hong, Zhengyan Zhao, Zhiqiang Wang, Wenhua Zhu   +40 more
semanticscholar   +1 more source

Mutation profile of the GNE gene in Japanese patients with distal myopathy with rimmed vacuoles (GNE myopathy)

Journal of Neurology, Neurosurgery & Psychiatry, 2013
GNE myopathy (also called distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy) is an autosomal recessive myopathy characterised by skeletal muscle atrophy and weakness that preferentially involve the distal muscles. It is caused by mutations in the gene encoding a key enzyme in sialic acid biosynthesis, UDP-N-acetylglucosamine 2 ...
Anna, Cho, Yukiko K, Hayashi, Kazunari, Monma, Yasushi, Oya, Satoru, Noguchi, Ikuya, Nonaka, Ichizo, Nishino   +6 more
openaire   +2 more sources

Therapeutic impacts of GNE-477-loaded H2O2 stimulus-responsive dodecanoic acid-phenylborate ester-dextran polymeric micelles on osteosarcoma

International Journal of Molecular Medicine
Osteosarcoma (OS) is a highly malignant primary bone neoplasm that is the leading cause of cancer-associated death in young people. GNE-477 belongs to the second generation of mTOR inhibitors and possesses promising potential in the treatment of OS but ...
Songmu Pan, Zhuan Zou, Xiaofeng Zhou, Jiyong Wei, Huijiang Liu, Zhongyi Su, Gui Liao, Guangyu Huang, Zonggui Huang, Yi Xu, Minan Lu, R. Gu   +11 more
semanticscholar   +1 more source

Ultra-Orphan drug development for GNE Myopathy: A synthetic literature review and meta-analysis

Journal of Neuromuscular Diseases
GNE myopathy is an autosomal recessive hereditary muscle disorder that has the following clinical characteristics: develops in early adulthood, gradually progresses from the distal muscles, and is relatively sparing of quadriceps until the advanced ...
Naoki Suzuki, M. Mori-Yoshimura, Ichizo Nishino, Masashi Aoki   +3 more
semanticscholar   +1 more source

PI3Kα inhibitor GNE-493 triggers antitumor immunity in murine lung cancer by inducing immunogenic cell death and activating T cells.

International Immunopharmacology
Phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer, playing pivotal roles in the pathophysiology of both malignant and immune cells.
X. Xue, Guanzhi Ye, Long Zhang, Xiaolei Zhu, Qun Liu, Gang Rui, Guo-jun Geng, Yihua Lin, Xiaohui Chen   +8 more
semanticscholar   +1 more source

Distributed GNE Seeking Strategy for Second-Integrator Multiplayer Systems Over Directed Topologies

IEEE Transactions on Neural Networks and Learning Systems
This article studies the generalized Nash equilibrium (GNE) seeking problem of second-integrator multiplayer systems. In particular, each player is endowed with an individual payoff function with respect to collective decision variables, and ...
Yao Zou, Yanghe Feng, Xiao-Na Song, M. Mughal, Wei He   +4 more
semanticscholar   +1 more source

Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1.

ACS Medicinal Chemistry Letters
Hematopoietic progenitor kinase 1 (HPK1) serves a key immunosuppressive role as a negative regulator of T-cell receptor (TCR) signaling. HPK1 loss-of-function is associated with augmentation of immune function and has demonstrated synergy with immune ...
J. Tellis, Binqing Wei, Michael Siu, Le An, Grace Ka Yan Chan, Yong Chen, Xiangnan Du, Lewis Gazzard, Baihua Hu, James Kiefer, Satoko Kakiuchi-Kiyota, M. Lainchbury, Jonathan L. Linehan, Xifeng Luo, Sushant Malhotra, Rohan V Mendonca, Jodie Pang, Yinqing Ran, V. Sethuraman, E. Seward, Chris Sneeringer, Dian Su, Weiru Wang, P. Wu, J. Moffat, Timothy Heffron, Edna F. Choo, Bryan K. Chan   +27 more
semanticscholar   +1 more source