Results 71 to 80 of about 15,103 (215)
Gene Editing for Haemophilia—The Next Frontier
Haemophilia, EarlyView.ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti +3 more
wiley +1 more source
A glycoprotein subunit vaccine elicits a strong Rift Valley fever virus neutralizing antibody response in sheep [PDF]
, 2014 Rift Valley fever virus (RVFV), a member of the Bunyaviridae family, is a mosquito-borne zoonotic pathogen that causes serious morbidity and mortality in livestock and humans.
Faburay, Bonto +6 more
core +1 more source
Pregnancy, Volume 2, Issue 3, May 2026.Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld +5 more
wiley +1 more source
Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression
Cancer Science, Volume 117, Issue 5, Page 1199-1208, May 2026.Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley +1 more source
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers [PDF]
, 2017 Aryl hydrocarbon receptor (AHR) is the key transcription factor that controls animal development and various adaptive processes. The AHR\u27s target genes are involved in biodegradation of endogenous and exogenous toxins, regulation of immune response ...
Akishina, Angelina A. +11 more
core +1 more source
Functional Mixture Discriminant Analysis with hidden process regression for curve classification
, 2013 We present a new mixture model-based discriminant analysis approach for functional data using a specific hidden process regression model. The approach allows for fitting flexible curve-models to each class of complex-shaped curves presenting regime ...
Chamroukhi, Faicel +2 more
core +4 more sources
Natriumbutyrat-induzierte Stimulation des humanen Gastrinpromotors und Identifizierung relevanter Response elements in den neuroendokrinen Pankreastumorzellen Bon I [PDF]
, 2006 Natriumbutyrat-induzierte Stimulation des humanen Gastrinpromotors und Identifizierung relevanter Response elements in den neuroendokrinen Pankreastumorzellen Bon ...
Freitag, Nicole +1 more
core +1 more source
GNE Myopathy in Turkish Sisters with a Novel Homozygous Mutation
Case Reports in Neurological Medicine, 2016 Background. Hereditary inclusion body myopathy is caused by biallelic defects in the GNE gene located on chromosome 9p13. It generally affects adults older than 20 years of age. Methods and Results.
Gulden Diniz +7 more
doaj +1 more source
BMC Genomics, 2022 Background Seizures are a common symptom in glioma patients, and they can cause brain dysfunction. However, the mechanism by which glioma-related epilepsy (GRE) causes alterations in brain networks remains elusive.
Zhi-Bin Wang +9 more
doaj +1 more source
Frontiers in Oncology, 2023 Analyzing gene expression profiles (GEP) through artificial intelligence provides meaningful insight into cancer disease. This study introduces DeepSHAP Autoencoder Filter for Genes Selection (DSAF-GS), a novel deep learning and explainable artificial ...
Fortunato Morabito +17 more
doaj +1 more source