Results 91 to 100 of about 15,103 (215)

Beyond Support in Two-Stage Variable Selection [PDF]

, 2015
Numerous variable selection methods rely on a two-stage procedure, where a sparsity-inducing penalty is used in the first stage to predict the support, which is then conveyed to the second stage for estimation or inference purposes.
Ambroise, Christophe, Bécu, Jean-Michel, Dalmasso, Cyril, Grandvalet, Yves   +3 more
core   +4 more sources

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

Barley yield formation under abiotic stress depends on the interplay between flowering time genes and environmental cues [PDF]

, 2019
Since the dawn of agriculture, crop yield has always been impaired through abiotic stresses. In a field trial across five locations worldwide, we tested three abiotic stresses, nitrogen deficiency, drought and salinity, using HEB-YIELD, a selected subset
Al-Abdallat, Ayed, Baum, Michael, Bull, Hazel J., Eglinton, Jason, Flavell, Andrew J., March, Timothy J., Maurer, Andreas, Pham, Anh, Pillen, Klaus, Shahid, Mohammed, Tester, Mark, Thomas, William T. B., Wiegmann, Mathias   +12 more
core   +4 more sources

Behavioral Deficits in Juvenile Onset Huntington’s Disease

Brain Sciences, 2020
Reports of behavioral disturbance in Juvenile-Onset Huntington’s Disease (JOHD) have been based primarily on qualitative caregiver reports or retrospective medical record reviews.
Kathleen E. Langbehn, Ashley M. Cochran, Ellen van der Plas, Amy L. Conrad, Eric Epping, Erin Martin, Patricia Espe-Pfeifer, Peg Nopoulos   +7 more
doaj   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Planck intermediate results. XXIX. All-sky dust modelling with Planck, IRAS, and WISE observations [PDF]

, 2015
We present all-sky modelling of the high resolution Planck, IRAS, and WISE infrared (IR) observations using the physical dust model presented by Draine and Li in 2007 (DL).
Ade, P. A. R., Aghanim, N., Alves, M. I. R., Aniano, G., Arnaud, M., Ashdown, M., Aumont, J., Baccigalupi, C., Banday, A. J., Barreiro, R. B., Bartolo, N., Battaner, E., Benabed, K., Benoit-Levy, A., Bernard, J. -P., Bersanelli, M., Bielewicz, P., Bonaldi, A., Bonavera, L., Bond, J. R., Borrill, J., Bouchet, F. R., Boulanger, F., Burigana, C., Butler, R. C., Calabrese, E., Cardoso, J. -F., Catalano, A., Chamballu, A., Chiang, H. C., Christensen, P. R., Clements, D. L., Colombi, S., Colombo, L. P. L., Couchot, F., Crill, B. P., Curto, A., Cuttaia, F., Danese, L., Davies, R. D., Davis, R. J., de Bernardis, P., de Rosa, A., de Zotti, G., Delabrouille, J., Dickinson, C., Diego, J. M., Dole, H., Donzelli, S., Dore, O., Douspis, M., Draine, B. T., Ducout, A., Dupac, X., Efstathiou, G., Elsner, F., Ensslin, T. A., Eriksen, H. K., Falgarone, E., Finelli, F., Forni, O., Frailis, M., Fraisse, A. A., Franceschi, E., Frejsel, A., Galeotta, S., Galli, S., Ganga, K., Ghosh, T., Giard, M., Gjerlow, E., Gonzalez-Nuevo, J., Gorski, K. M., Gregorio, A., Gruppuso, A., Guillet, V., Hansen, F. K., Hanson, D., Harrison, D. L., Henrot-Versille, S., Hernandez-Monteagudo, C., Herranz, D., Hildebrandt, S. R., Hivon, E., Holmes, W. A., Hovest, W., Huffenberger, K. M., Hurier, G., Jaffe, A. H., Jaffe, T. R., Jones, W. C., Keihanen, E., Keskitalo, R., Kisner, T. S., Kneissl, R., Knoche, J., Kunz, M., Kurki-Suonio, H., Lagache, G., Lamarre, J. -M., Lasenby, A., Lattanzi, M., Lawrence, C. R., Leonardi, R., Levrier, F., Liguori, M., Lilje, P. B., Linden-Vornle, M., Lopez-Caniego, M., Lubin, P. M., Macias-Perez, J. F., Maffei, B., Maino, D., Mandolesi, N., Maris, M., Marshall, D. J., Martin, P. G., Martinez-Gonzalez, E., Masi, S., Matarrese, S., Mazzotta, P., Melchiorri, A., Mendes, L., Mennella, A., Migliaccio, M., Miville-Deschenes, M. -A., Moneti, A., Montier, L., Morgante, G., Mortlock, D., Munshi, D., Murphy, J. A., Naselsky, P., Natoli, P., Norgaard-Nielsen, H. U., Novikov, D., Novikov, I., Oxborrow, C. A., Pagano, L., Pajot, F., Paladini, R., Paoletti, D., Pasian, F., Perdereau, O., Perotto, L., Perrotta, F., Pettorino, V., Piacentini, F., Piat, M., Plank Collaboration, Plaszczynski, S., Pointecouteau, E., Polenta, G., Ponthieu, N., Popa, L., Pratt, G. W., Prunet, S., Puget, J. -L., Rachen, J. P., Reach, W. T., Rebolo, R., Reinecke, M., Remazeilles, M., Renault, C., Ristorcelli, I., Rocha, G., Roudier, G., Rubio-Martin, J. A., Rusholme, B., Sandri, M., Santos, D., Scott, D., Spencer, L. D., Stolyarov, V., Sudiwala, R., Sunyaev, R., Sutton, D., Suur-Uski, A. -S., Sygnet, J. -F., Tauber, J. A., Terenzi, L., Toffolatti, L., Tomasi, M., Tristram, M., Tucci, M., Umana, G., Valenziano, L., Valiviita, J., Van Tent, B., Vielva, P., Villa, F., Wade, L. A., Wandelt, B. D., Wehus, I. K., Ysard, N., Yvon, D., Zacchei, A., Zonca, A.   +197 more
core   +11 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Clinical and Genomic Evaluation of 207 Genetic Myopathies in the Indian Subcontinent

Frontiers in Neurology, 2020
Objective: Inherited myopathies comprise more than 200 different individually rare disease-subtypes, but when combined together they have a high prevalence of 1 in 6,000 individuals across the world.
Samya Chakravorty, Samya Chakravorty, Samya Chakravorty, Samya Chakravorty, Babi Ramesh Reddy Nallamilli, Satish Vasant Khadilkar, Satish Vasant Khadilkar, Satish Vasant Khadilkar, Madhu Bala Singla, Madhu Bala Singla, Madhu Bala Singla, Ashish Bhutada, Rashna Dastur, Pradnya Satish Gaitonde, Laura E Rufibach, Logan Gloster, Logan Gloster, Madhuri Hegde, Madhuri Hegde   +18 more
doaj   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

The Granulocyte colony-stimulating factor produces long-term changes on gene and miRNA expression profiles in CD34+ cells from healthy donors [PDF]

, 2014
Granulocyte colony-stimulating factor is the most commonly used cytokine for the mobilization of hematopoietic progenitor cells from healthy donors for allogeneic stem cell transplantation. Although the administration of this cytokine is considered safe,
Barbado González, Mª Victoria, Báez Palomo, Alicia, Carmona González, Magdalena, Martín Antonio, Beatriz, Piruat Palomo, José Ignacio, Prats Martín, Concepción, Pérez Simón, José Antonio, Urbano Ispizua, Álvaro, Álvarez Laderas, Isabel   +8 more
core   +2 more sources