Results 201 to 210 of about 194,150 (247)
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Effect of a GnRH antagonist on GnRH agonist–implanted anestrous bitches
Theriogenology, 2009Various combinations of gonadotropin-releasing hormone (GnRH) antagonists and long-acting GnRH agonists have been assessed in several species to prevent the "flare-up" effect that agonists cause on the pituitary-gonadal axis. To determine the effect of a single administration of the GnRH antagonist acyline in anestrous GnRH agonist-implanted domestic ...
C, Valiente +5 more
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GnRH Agonists and Antagonists in Cancer Therapy
Current Medicinal Chemistry-Anti-Cancer Agents, 2003Gonadotropin releasing hormone (GnRH) is a hypothalamic decapeptide that binds to GnRH receptors on pituitary gonadotrope cells to modulate the synthesis and secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These gonadotropins in turn regulate gonadal steroidogenesis and gametogenesis.
Murty V, Chengalvala +2 more
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[GnRH-agonists in gynecology I].
Ginecologia y obstetricia de Mexico, 1992The present review has the objective to describe the chemical and pharmacological characteristics of GnRH analogs and the present time indications of it's use in gynecology. It is a critical review about use of GnRH analogs in: Anticonception, Assisted Reproduction, Uterine leiomyomas, Endometriosis, Polycystic Ovarian Syndrome, Precosious Puberty ...
T, Herrera Suastegui +3 more
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GnRH Agonists, Antagonists, and Assisted Conception
Seminars in Reproductive Medicine, 2002Pituitary stimulation with pulsatile gonadotropin-releasing hormone (GnRH) induces both follicle-stimulating hormone and luteinizing hormone (LH). Blockade of pituitary gonadotropin secretion occurs upon desensitization when a continuous GnRH stimulus is provided by means an agonist or when the pituitary receptors are occupied with a competitive ...
André C D, van Loenen +4 more
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GnRH agonists in the treatment of endometriosis.
Acta Europaea fertilitatis, 1988GnRH agonists, synthetic peptide analogs of GnRH, desensitize pituitary receptors for the native molecule, thus causing reversible hypogonadotropic hypogonadism. Numerous clinical studies have suggested that these compounds are efficacious in the treatment of endometriosis, but it is not clear whether they are superior to the other drugs used in ...
L. Fedele +4 more
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Gonadotrophin-releasing hormone (GnRH) and GnRH agonists: mechanisms of action
Reproductive BioMedicine Online, 2002The hypothalamic decapeptide gonadotrophin-releasing hormone (GnRH) binds to specific receptors on pituitary gonadotrophs. These receptors belong to the family of G protein-coupled receptors. Their activation leads to phosphoinositide breakdown with generation of inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and diacylglycerol.
O, Ortmann, J M, Weiss, K, Diedrich
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GnRH agonists—antagonists — clinical applications
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1988We know that there is a wide range of clinical applications for GnRH analogues in the field of benign gynaecological disorders. As we understand more of the physiology and mechanism of these GnRH agonists, and there appear more varied and perhaps efficient delivery systems, and antagonists become available, it may be possible to develop a graded ...
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Use of GnRH agonists in hysteroscopic surgery
The Journal of the American Association of Gynecologic Laparoscopists, 1994Medical reduction of the endometrium before hysteroscopic procedures has been demonstrated by many authors. In endometrial ablation, the GnRH agonists are useful for endometrial reduction and correction of anemia preoperatively. However, in cases of emergency, (severe hemorrhage), mechanical reduction (D&C) or other drugs like danazol work quicker. The
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Use of the GnRH-agonist (GnRH-A) in gynaecology.
1998GnRH-agonist therapy is used in the management of many gynaecological pathologies: uterine fibroids, endometriosis, ovarian cystic pathology, breast cancer, dysfunctional uterine bleeding and, in males, prostatic cancer. In the case of uterine fibroids, this therapy can be used as a pre-treatment before conservative or demolitive surgery or as an ...
CIARDO A, SPINA V, ALEANDRI, Vincenzo
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GnRH analogoues-agonists and antagonists
2008GnRH analogues have achieved widespread clinical use for control of reproduction in animals. Over 2000 analogues of GnRH have been developed and tested the last 30 years. Paradoxical anti-fertility effects are seen when the more potent agonists are delivered continuosly to animals.
Adib Neishaboori, .M +2 more
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