Results 231 to 240 of about 7,767,661 (277)
British Journal of Clinical Pharmacology, EarlyView.Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci +10 more
wiley +1 more source
The global extent of polypharmacy in neonatal intensive care: A systematic review
British Journal of Clinical Pharmacology, EarlyView.Aims Pharmaceutical treatment in the neonatal intensive care unit (NICU) is challenging, with neonates often receiving multiple drugs during hospitalization. Given their physiological immaturity, polypharmacy raises concerns about potential adverse effects, drug–drug interactions and the risk of supratherapeutic or subtherapeutic treatment.
Mia Finserås Bretun +6 more
wiley +1 more source
British Educational Research Journal, EarlyView.Abstract All children should have access to quality education through a child‐centred pedagogy. An inclusive, child‐centred pedagogy uses a strength‐based view of children that recognises each child as unique and competent, providing children with multiple opportunities to explore and learn at their own pace.
Katherine Gulliver
wiley +1 more source
Goal-Directed Fluid Therapy for Oesophagectomy Surgery [PDF]
British Journal of Anaesthesia, 2021 Jean-Louis Vincent +2 more
exaly +3 more sources
Goal-Directed Fluid Therapy in Emergency Abdominal Surgery: A Randomised Multicentre Trial
British Journal of Anaesthesia, 2021 More than 50% of patients have a major complication after emergency gastrointestinal surgery. Intravenous (i.v.) fluid therapy is a life-saving part of treatment, but evidence to guide what i.v. fluid strategy results in the best outcome is lacking. We hypothesised that goal-directed fluid therapy during surgery (GDT group) reduces the risk of major ...
Erik Zimmermann-Nielsen +2 more
exaly +5 more sources
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Limits of Goal-Directed Fluid Therapy or Limits of Fluid Restriction?
British Journal of Anaesthesia, 2022Tuong Phan, Philip Peyton
exaly +3 more sources
Current Pharmaceutical Design, 2012
The cornerstone of treating patients with shock remains as it has for decades, intravenous fluids. Surprisingly, dosing intravenous fluid during resuscitation of shock remains largely empirical. Recent data suggests that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia, progression to organ failure and ...
Paul E, Marik, Himanshu, Desai
openaire +4 more sources
The cornerstone of treating patients with shock remains as it has for decades, intravenous fluids. Surprisingly, dosing intravenous fluid during resuscitation of shock remains largely empirical. Recent data suggests that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia, progression to organ failure and ...
Paul E, Marik, Himanshu, Desai
openaire +4 more sources