Results 81 to 90 of about 11,733,399 (339)
The application of and unresolved problems regarding the use of objectives in software engineering
Ingeniería e Investigación, 2012 One of the first items which should be identified in resolving a problem or need is an objective in the various fields of knowledge as it enables determining which results must be achieved.
Luis Alfonso Lezcano Rodríguez +2 more
doaj
ACQUISITION OF BASIC PUBLIC SPEAKING SKILLS
BizInfo, 2017 With this texst we show that the acquisition of oratorical skills means not only mastering certain techniques of oratory, or public speaking, but that this is largely primarily related with a kind of mental preparation of speakers themselves, or in which
Nataša Novaković, Boris Teodosijević
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Teachers’ Professional Development in the Framework of the New Federal State Educational Standards
Образование и наука, 2015 The paper considers a contradiction between the great demand for teachers’ professional development, induced by the new Federal State Educational Standards, and the lack of relevant training programs for school teachers. The author has conducted a survey
Y. A. Sidenko
doaj +1 more source
The Concept of Telicity in English, Romanian and Serbian
Romanian Journal of English Studies, 2020 Given that the notion of telicity was simply defined by English linguists as a situation which tends towards a goal, this paper will additionally explain and define telicity in the English language.
Lazović Mihaela
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Goal-oriented Dialogue Policy Learning from Failures
, 2018 Reinforcement learning methods have been used for learning dialogue policies. However, learning an effective dialogue policy frequently requires prohibitively many conversations. This is partly because of the sparse rewards in dialogues, and the very few
Chen, Xiaoping, Lu, Keting, Zhang, Shiqi
core +1 more source
An Expert Consensus Framework for Asthma Remission as a Treatment Goal.
Journal of Allergy and Clinical Immunology, 2019 With novel therapies in development, there is an opportunity to consider asthma remission as a treatment goal. In this Rostrum, we present a generalized framework for clinical and complete remission in asthma, on and off treatment, developed based on ...
Andrew Menzies-Gow +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source