Results 61 to 70 of about 1,244,663 (305)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Narrative episodic future thinking reduces delay discounting and enhances goal salience in the general population: an online feasibility study

Health Psychology and Behavioral Medicine
Background: Delay discounting is the tendency when people choose an immediate smaller reward over a delayed, larger reward in decision-making. Higher delay discounting is associated with maladaptive behaviours that can interfere with long-term goal ...
Chantelle Boucher, Timothy Skinner, Carina K. Y. Chan   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Type of goals and perceived control for goal achievement over time. The mediating role of motivational persistence

Acta Psychologica, 2022
This study tested how type of goals (i.e., performance and mastery goals) influence perceived control for goal achievement over time (i.e., after 12 months) while controlling for motivational persistence, gender, self-efficacy, initial perceived control,
Cristina Maria Bostan, Alexandru-Cosmin Apostol, Răzvan-Lucian Andronic, Tudor Stanciu, Ticu Constantin   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Role of Needs Assessment in the Success and Sustainability of Humanitarian Projects in Hadramout

مجلة التمكين الاجتماعي
This study aims to highlight the importance of needs assessment as a strategic tool for enhancing the effectiveness and efficiency of humanitarian projects in Hadhramaut Governorate, from the perspectives of data collectors, monitoring and evaluation ...
Etfak Khalid Yaseen Noman AlDubai, Abdulwahab Abdullah Al-maamari   +1 more
doaj   +1 more source

THE DYNAMICS OF PESANTREN: Responses toward Modernity and Mechanism in Organizing Transformation

Journal of Indonesian Islam, 2011
The development of pesantren from time to time illustrates its significant role within communities. Its dynamic development appears clearly as a result of its ability to adapt into the external condition.
Hanun Asrohah
doaj   +1 more source

Demographic Variations in Achievement Goal Orientations among Prisoners on Formal and Vocational Training in Uganda [PDF]

, 2018
Educating Prisoners has become a worldwide concern as a measure that can save community costs associated with criminal behavior. In Uganda, there is low participation in formal and vocational training among prisoners which can be associated with lack of ...
Aheisibwe, Irene, Rukundo, Aloysius
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Gender differences in the correlates of academic achievement among university students [PDF]

, 2017
Purpose: Prior research has highlighted gender differences in academic motivational attributes, and how these predict academic achievement for each gender, however, a vast amount of inconsistency exists amongst such literature.
Boduszek, Daniel, Debowska, Agata, Pirmohamed, Sarah   +2 more
core   +1 more source