Results 121 to 130 of about 6,816,256 (279)

Effect of goal-directed haemodynamic therapy in free flap reconstruction for head and neck cancer

, 2018
BACKGROUND: In free flap reconstruction for head and neck cancer, achieving a haemodynamic target using excessive fluid infusion is associated with decreased flap survival rates and extended hospital stays. We hypothesized that goal-directed haemodynamic
김현주, 김은정, 최은창, 구본녀, 민지영   +4 more
core   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Goal-Directed Fluid Therapy in Sepsis and Septic Shock: A Review of Current Therapeutic Strategies and Outcomes

Journal of Education, Health and Sport
Introduction and purpose: Sepsis induces profound microvascular derangements, making prompt fluid resuscitation a management cornerstone. Historically guided by Early Goal-Directed Therapy (EGDT), landmark trials have refuted EGDT's rigidity, driving a ...
Maciej Dobrucki, Katarzyna Jolanta Kuc, Krzysztof Brzezicki, Katarzyna Zegadło, Mateusz Cieciora, Aleksandra Cieciora, Patryk Jakubiak, Małgorzata Kawiorska, Julia Surowiec, Wiktoria Ruta Bełcikowska-Skowron   +9 more
doaj   +1 more source

Goal-directed Fluid Therapy in Neurosurgery: Three Feet from Gold? [PDF]

Indian J Crit Care Med, 2023
Kothekar AT, Mohanty R, Joshi AV.
europepmc   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Stroke volume averaging for individualized goal-directed fluid therapy with oesophageal Doppler

, 2009
BACKGROUND: An individualized fluid optimization strategy, based on maximization of cardiac stroke volume (SV) with colloid boluses (goal-directed therapy), improves outcome after surgery.
Bundgaard-Nielsen, M., Kehlet, H., Secher, Niels H., Skovgaard, Lene Theil, Jorgensen, C.C.   +4 more
core   +1 more source

The effect of goal-directed crystalloid versus colloid administration on postoperative spirometry parameters: a substudy of a randomized controlled clinical trial

Perioperative Medicine
Background Pulmonary function is impaired after major abdominal surgery and might be less impaired by restrictive fluid administration. Under the assumption of a fluid-sparing effect of colloids, we tested the hypothesis that an intraoperative colloid ...
Mina Obradovic, Florian Luf, Christian Reiterer, Sebastian Schoppmann, Andrea Kurz, Edith Fleischmann, Barbara Kabon   +6 more
doaj   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source