Results 181 to 190 of about 492,841 (300)

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Efficacy of Early Goal-Directed Therapy in Septic Shock Management: A Systematic Review. [PDF]

Cureus
Acharya P, Virani S, Afreen S, Perthiani A, Sangster E, Lanka N, Malasevskaia I.   +6 more
europepmc   +1 more source

Comparison of Intermittent versus Continuous Superior Venal Caval Oxygen Saturation Monitoring in Early Goal Directed Therapy in Septic Shock: A Systematic Review. [PDF]

J Pediatr Intensive Care, 2022
Sankar JM, Das RR, Kumar UV.
europepmc   +1 more source

Conductive Hydrogels for Exogenous Sensing and Cell Fate Control

Advanced Materials, EarlyView.
We engineer electrically conductive hydrogels by combining sulfated glycosaminoglycans with semiconducting polymers. These hydrogels bind bioactive proteins, including growth factors, whose release or retention can be modulated by low‐voltage stimulation. The hydrogels are also integrated as 3D channels in organic electrochemical transistors as part of
Teuku Fawzul Akbar, Carlos Alejandro Jimenez‐Rodriguez, Railia Biktimirova, Ilka Hermes, Thomas Kurth, My Duyen Pham, Mikhail Tsurkan, Jens Friedrichs, Francis L. C. Morgan, Hans Kleemann, Olga Guskova, Uwe Freudenberg, Peter Fratzl, Carsten Werner, Christoph Tondera, Ivan R. Minev   +15 more
wiley   +1 more source

Autonomous Cargo Transport with Biohybrid Microswimmers Enabled by Light‐Mediated Bacteria‐Cargo Communication

Advanced Materials, EarlyView.
ABSTRACT Biohybrid microswimmers, which integrate the unique mobility and taxis of living cells with the versatility of synthetic cargo, offer exciting opportunities for targeted delivery. However, current biohybrids lack autonomous decision‐making capabilities due to the absence of communication between living and synthetic components. Here, we report
Xiaoran Zheng, Yanjun Zheng, Ali Heidari, Seraphine V. Wegner   +3 more
wiley   +1 more source

"Early goal-directed therapy" versus "Early" and "goal-directed" therapy for severe sepsis and septic shock: Time to rationalize

Lung India, 2015
Sahajal Dhooria, Ritesh Agarwal
doaj  

Correction of Trauma-induced Coagulopathy by Goal-directed Therapy: A Secondary Analysis of the ITACTIC Trial. [PDF]

Anesthesiology
Lindsay C, Davenport R, Baksaas-Aasen K, Kolstadbråten KM, Naess PA, Curry N, Maegele M, Juffermans N, Stanworth S, Stensballe J, Johansson PI, Gaarder C, Brohi K.   +12 more
europepmc   +1 more source

The effect of compliance with a perioperative goal-directed therapy protocol on outcomes after high-risk surgery: a before-after study. [PDF]

J Clin Monit Comput, 2021
Boekel MF, Venema CS, Kaufmann T, van der Horst ICC, Vos JJ, Scheeren TWL.   +5 more
europepmc   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

To: Goal-directed therapy guided by the FloTrac sensor in major surgery: a systematic review and meta-analysis. [PDF]

Crit Care Sci
Via L, Cusumano G, Zanza C, Calvagna C, Maniaci A.   +4 more
europepmc   +1 more source