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Advanced Science, EarlyView.This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu +9 more
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Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
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2021
Since the publication of the landmark paper by Dr. Emanuel Rivers in The New England Journal of Medicine in 2001, the world of critical care massively adopted his protocol for the resuscitation of severe sepsis and/or septic shock—which was named “early goal-directed therapy” [1].
Pasquale Nardelli +2 more
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Since the publication of the landmark paper by Dr. Emanuel Rivers in The New England Journal of Medicine in 2001, the world of critical care massively adopted his protocol for the resuscitation of severe sepsis and/or septic shock—which was named “early goal-directed therapy” [1].
Pasquale Nardelli +2 more
openaire +1 more source
Current Pharmaceutical Design, 2012
The cornerstone of treating patients with shock remains as it has for decades, intravenous fluids. Surprisingly, dosing intravenous fluid during resuscitation of shock remains largely empirical. Recent data suggests that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia, progression to organ failure and ...
Paul E, Marik, Himanshu, Desai
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The cornerstone of treating patients with shock remains as it has for decades, intravenous fluids. Surprisingly, dosing intravenous fluid during resuscitation of shock remains largely empirical. Recent data suggests that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia, progression to organ failure and ...
Paul E, Marik, Himanshu, Desai
openaire +2 more sources
Critical Care Medicine, 2004
In a single center, randomized controlled trial, EGDT has been shown to reduce mortality by 16% in patients presenting to the emergency department with sepsis or septic shock. However, widespread implementation of EGDT will require a collaborative effort between multiple disciplines (physicians, nurses, allied health personnel) as well as multiple ...
Emanuel P. Rivers +3 more
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In a single center, randomized controlled trial, EGDT has been shown to reduce mortality by 16% in patients presenting to the emergency department with sepsis or septic shock. However, widespread implementation of EGDT will require a collaborative effort between multiple disciplines (physicians, nurses, allied health personnel) as well as multiple ...
Emanuel P. Rivers +3 more
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Goal-Directed Therapy for Cardiac Surgery
Critical Care Clinics, 2020Goal-directed therapy couples therapeutic interventions with physiologic and metabolic targets to mitigate a patient's modifiable risks for death and complications. Goal-directed therapy attempts to improve quality-of-care metrics, including length of stay, rate of readmission, and cost per case.
Kevin W, Lobdell +2 more
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Early goal-directed therapy versus “early”, “goal-directed” therapy
Intensive Care Medicine, 2015Dear Editor, I read with great interest the systematic review and meta-analysis by the ARISE, ProCESS and ProMISe investigators [1] that showed no difference in mortality between early goal-directed therapy (EGDT) and usual care in resuscitating patients with septic shock. I admire their work and this is a great opportunity to speak directly with them.
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