Results 41 to 50 of about 222,136 (307)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Goal confidence and difficulty as predictors of goal attainment in junior high school cross-country runners

, 1997
This study examined the influence of confidence in a goal and difficulty of the goal on the attainment of self-set goals regarding time and position. 63 Junior high school cross-country runners (M Age=13.5 yr., SD=.5 yr.) completed a 6-item Race Goals ...
Lane, AM, Andrew M. Lane, Costas I. Karageorghis, Karageorghis, CI   +3 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Metam: Goal-Oriented Data Discovery

2023 IEEE 39th International Conference on Data Engineering (ICDE), 2023
ICDE 2023 ...
Sainyam Galhotra, Yue Gong, Raul Castro Fernandez   +2 more
openaire   +2 more sources

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Willing and able: action-state orientation and the relation between procedural justice and employee cooperation

, 2013
Existing justice theory explains why fair procedures motivate employees to adopt cooperative goals, but it fails to explain how employees strive towards these goals.
De Cremer, D (David), Niels Van Quaquebeke, Van Quaquebeke, N, Lieven Brebels, De Cremer, D, van Quaquebeke, Niels, van Dijke, Marius; id_orcid, van Dijke, Marius, Van Dijke, M, De Cremer, David, Brebels, Lieven, Brebels, LGG, David De Cremer, Brebels, L, Marius van Dijke   +14 more
core   +1 more source

Predicting race performance in triathlon: The role of perfectionism, achievement goals, and personal goal setting [PDF]

, 2009
The question of how perfectionism affects performance is highly debated. Because empirical studies examining perfectionism and competitive sport performance are missing, the present research investigated how perfectionism affected race performance and ...
Stoeber, Joachim, Hotham, Sarah, Uphill, Mark A.   +2 more
core   +1 more source

GOAL ORIENTATION DAN SUBJECTIVE WELL BEING PADA LANSIA

Jurnal Psikologi Undip, 2017
This study aimed to examine the relationship between goal orientation and subjective well-being in the elderly, which includes psychological well-being, emotional well-being and social well-being.
Dinie Ratri Desiningrum
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source