Results 51 to 60 of about 1,008,460 (342)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser +5 more
wiley +1 more source
A goal geometric programming problem (G 2 P 2) with logarithmic deviational variables and its applications on two industrial problems [PDF]
, 2013 A very useful multi-objective technique is goal programming. There are many methodologies of goal programming such as weighted goal programming, min-max goal programming, and lexicographic goal programming.
Ghosh, Payel, Roy, Tapan
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Surgical Operation Scheduling with Goal Programming and Constraint Programming: A Case Study
Mathematics, 2019 The achievement of health organizations’ goals is critically important for profitability. For this purpose, their resources, materials, and equipment should be efficiently used in the services they provide.
Şeyda Gür +2 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
A Visual Programming Paradigm for Abstract Deep Learning Model Development
, 2019 Deep learning is one of the fastest growing technologies in computer science with a plethora of applications. But this unprecedented growth has so far been limited to the consumption of deep learning experts.
Aralikatte, Rahul +5 more
core +1 more source
A Concurrent Language with a Uniform Treatment of Regions and Locks [PDF]
, 2010 A challenge for programming language research is to design and implement multi-threaded low-level languages providing static guarantees for memory safety and freedom from data races.
Gerakios, Prodromos +2 more
core +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
An optimization model for production planning in the drying sector of an industrial laundry
Acta Scientiarum: Technology, 2017 In this work, an optimization model was developed for production planning in the drying sector of a real industrial laundry. Goal programming was used in order to minimize energy and labor costs, and to use of the full capacity of each piece of equipment,
Eduardo Alves Oliveira +2 more
doaj +1 more source