Results 41 to 50 of about 3,156,760 (295)

A goal programming procedure for solving fuzzy multiobjective fractional linear programming problems

open access: yesCroatian Operational Research Review, 2014
This paper presents a modification of Pal, Moitra and Maulik's goal programming procedure for fuzzy multiobjective linear fractional programming problem solving.
Tunjo Perić, Zoran Babić, Sead Rešić
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Fuzzy goal programming for agricultural land allocation problems [PDF]

open access: yesYugoslav Journal of Operations Research, 2007
This paper presents a fuzzy goal programming (FGP) approach for optimal allocation of land under cultivation and proposes an annual agricultural plan for different crops.
Sharma Dinesh K.   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Introducing a New Approach in Stand Tending Planning and Thinning Block Designation by Using Mixed Integer Goal Programming

open access: yesCroatian Journal of Forest Engineering, 2022
Long-term management plans have been developed for nearly all of the forests in Turkey. These plans are applied at a sub-district management unit level and may contain guidance for both intermediate yield and final yield harvests.
Mehmet Demirci   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Goal programming approach to fully fuzzy fractional transportation problem

open access: yesJournal of Taibah University for Science, 2019
In this paper, authors devoted to study a fully fuzzy fractional multi-objective transportation problem by using goal programming approach. Also trapezoidal membership functions are applied to each objective function and constraints to describe a each ...
P. Anukokila, B. Radhakrishnan
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

What Does Aspect−Oriented Programming Mean for Functional Programmers? [PDF]

open access: yes, 2009
Aspect-Oriented Programming (AOP) aims at modularising crosscutting concerns that show up in software. The success of AOP has been almost viral and nearly all areas in Software Engineering and Programming Languages have become "infected" by the AOP bug ...
Oliveira, BCDS   +7 more
core   +1 more source

Surgical Operation Scheduling with Goal Programming and Constraint Programming: A Case Study

open access: yesMathematics, 2019
The achievement of health organizations’ goals is critically important for profitability. For this purpose, their resources, materials, and equipment should be efficiently used in the services they provide.
Şeyda Gür   +2 more
doaj   +1 more source

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